New developments implicating IL-21 in autoimmune disease.

Animals Autoimmune Diseases / blood CD8-Positive T-Lymphocytes / immunology Cell Differentiation / immunology Disease Models, Animal Humans Immunologic Memory Interleukins / metabolism Receptors, Interleukin-21 / metabolism Signal Transduction / immunology T Follicular Helper Cells / immunology
Autoimmunity CD4 T cells CD8 T cells Interleukin (IL)-21 Resident memory

Journal

Journal of autoimmunity
ISSN: 1095-9157
Titre abrégé: J Autoimmun
Pays: England
ID NLM: 8812164

Informations de publication

Date de publication:
08 2021
Historique:
received: 15 06 2021
accepted: 23 06 2021
pubmed: 6 7 2021
medline: 9 2 2022
entrez: 5 7 2021
Statut: ppublish

Résumé

Elevated interleukin (IL)-21 is a common finding in the tissues and/or sera of patients with autoimmune disease. CD4 T cells are the primary producers of IL-21; often the IL-21 producing CD4 T cells will express molecules associated with follicular helper cells (T

Identifiants

DOI: 10.1016/j.jaut.2021.102689 PMID: 34224936 PMC: PMC8293794
pubmed: 34224936
pii: S0896-8411(21)00097-4
doi: 10.1016/j.jaut.2021.102689
pmc: PMC8293794
mid: NIHMS1721479
pii:
doi:

Substances chimiques

Interleukins 0
Receptors, Interleukin-21 0
interleukin-21 MKM3CA6LT1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102689

Subventions

Organisme : NIAID NIH HHS
ID : F31 AI142997
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS088367
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092662
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

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Auteurs

Heather M Ren (HM)

MD/PhD Medical Scientist Training Program at Penn State College of Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA; Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA, 17033, USA. Electronic address: hschmitz@pennstatehealth.psu.edu.

Aron E Lukacher (AE)

Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA, 17033, USA.

Ziaur S M Rahman (ZSM)

Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA, 17033, USA.

Nancy J Olsen (NJ)

Devision of Rheumatology, Department of Medicine, Penn State MS Hershey Medical Center, Hershey, PA, 17033, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › New developments implicating IL-21 in...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › New developments implicating IL-21 in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › New developments implicating IL-21 in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › New developments implicating IL-21 in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › New developments implicating IL-21 in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › New developments implicating IL-21 in...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › New developments implicating IL-21 in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › New developments implicating IL-21 in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-21 › New developments implicating IL-21 in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › New developments implicating IL-21 in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes T auxiliaires folliculaires › New developments implicating IL-21 in...