Artemisia scoparia promotes adipogenesis in the absence of adipogenic effectors.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
09
04
2021
received:
03
02
2021
accepted:
13
04
2021
pubmed:
7
7
2021
medline:
26
11
2021
entrez:
6
7
2021
Statut:
ppublish
Résumé
Extracts of Artemisia scoparia (SCO) have antidiabetic properties in mice and enhance adipogenesis in vitro, but the underlying mechanisms are unknown. Thiazolidinediones, including rosiglitazone (ROSI), are pharmacological activators of peroxisome proliferator-activated receptor gamma that also promote adipogenesis. The aim of this study was to examine adipogenic pathways responsible for SCO-mediated adipogenesis and identify potential differences between SCO and ROSI in the ability to promote adipocyte development. The ability of SCO or ROSI to promote adipogenesis in 3T3-L1 cells following systematic omission of the common triad of adipogenic effectors dexamethasone, 1-methyl-3-isobutylxanthine (MIX), and insulin was examined. Adipogenesis was assessed by both neutral lipid quantitation and adipocyte marker gene expression. The results demonstrate that SCO and ROSI promote adipogenesis and increase the expression of several peroxisome proliferator-activated receptor gamma target genes involved in lipid accumulation in the absence of MIX. However, ROSI can enhance adipogenesis in the absence of MIX and insulin and differentially regulates adipogenic and lipid metabolism genes as compared with SCO. These data demonstrate the adipogenic capabilities of SCO are similar but not identical to ROSI, thereby warranting further research into SCO as a promising source of therapeutic compounds in the treatment of metabolic disease states.
Identifiants
pubmed: 34227239
doi: 10.1002/oby.23199
pmc: PMC8883808
mid: NIHMS1779619
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1309-1319Subventions
Organisme : NCCIH NIH HHS
ID : P50 AT002776
Pays : United States
Organisme : NCCIH NIH HHS
ID : T32 AT004094
Pays : United States
Organisme : NCCIH NIH HHS
ID : T32AT00409
Pays : United States
Organisme : NCCIH NIH HHS
ID : P50AT002776
Pays : United States
Informations de copyright
© 2021 The Obesity Society.
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