Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain.
NREMS
arousal
gamma power
infraslow
insomnia
mouse
neuroscience
spared-nerve-injury
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
06 07 2021
06 07 2021
Historique:
received:
16
12
2020
accepted:
02
07
2021
pubmed:
7
7
2021
medline:
29
10
2021
entrez:
6
7
2021
Statut:
epublish
Résumé
Frequent nightly arousals typical for sleep disorders cause daytime fatigue and present health risks. As such arousals are often short, partial, or occur locally within the brain, reliable characterization in rodent models of sleep disorders and in human patients is challenging. We found that the EEG spectral composition of non-rapid eye movement sleep (NREMS) in healthy mice shows an infraslow (~50 s) interval over which microarousals appear preferentially. NREMS could hence be vulnerable to abnormal arousals on this time scale. Chronic pain is well-known to disrupt sleep. In the spared nerve injury (SNI) mouse model of chronic neuropathic pain, we found more numerous local cortical arousals accompanied by heart rate increases in hindlimb primary somatosensory, but not in prelimbic, cortices, although sleep macroarchitecture appeared unaltered. Closed-loop mechanovibrational stimulation further revealed higher sensory arousability. Chronic pain thus preserved conventional sleep measures but resulted in elevated spontaneous and evoked arousability. We develop a novel moment-to-moment probing of NREMS vulnerability and propose that chronic pain-induced sleep complaints arise from perturbed arousability.
Identifiants
pubmed: 34227936
doi: 10.7554/eLife.65835
pii: 65835
pmc: PMC8291975
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Cardis et al.
Déclaration de conflit d'intérêts
RC, SL, LF, AO, SF, ID, AL none, PC None
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