Lactate sensing mechanisms in arterial chemoreceptor cells.
Animals
Arteries
/ metabolism
Carotid Body
/ metabolism
Chemoreceptor Cells
/ metabolism
Homeostasis
Hydrogen-Ion Concentration
Hypoxia
/ metabolism
Ion Channels
/ metabolism
Lactic Acid
/ metabolism
Mitochondria
/ metabolism
Oxygen
/ metabolism
Phosphorylation
Reactive Oxygen Species
/ metabolism
Reflex
Signal Transduction
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 07 2021
06 07 2021
Historique:
received:
21
07
2020
accepted:
08
06
2021
entrez:
7
7
2021
pubmed:
8
7
2021
medline:
27
7
2021
Statut:
epublish
Résumé
Classically considered a by-product of anaerobic metabolism, lactate is now viewed as a fundamental fuel for oxidative phosphorylation in mitochondria, and preferred over glucose by many tissues. Lactate is also a signaling molecule of increasing medical relevance. Lactate levels in the blood can increase in both normal and pathophysiological conditions (e.g., hypoxia, physical exercise, or sepsis), however the manner by which these changes are sensed and induce adaptive responses is unknown. Here we show that the carotid body (CB) is essential for lactate homeostasis and that CB glomus cells, the main oxygen sensing arterial chemoreceptors, are also lactate sensors. Lactate is transported into glomus cells, leading to a rapid increase in the cytosolic NADH/NAD
Identifiants
pubmed: 34230483
doi: 10.1038/s41467-021-24444-7
pii: 10.1038/s41467-021-24444-7
pmc: PMC8260783
doi:
Substances chimiques
Ion Channels
0
Reactive Oxygen Species
0
Lactic Acid
33X04XA5AT
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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