GABA-receptive microglia selectively sculpt developing inhibitory circuits.
cerebral cortex
development
glia-neuron interactions
inhibitory synapses
interneurons
microglia
neurodevelopmental disorders
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
22 07 2021
22 07 2021
Historique:
received:
12
09
2020
revised:
31
03
2021
accepted:
10
06
2021
pubmed:
8
7
2021
medline:
6
1
2022
entrez:
7
7
2021
Statut:
ppublish
Résumé
Microglia, the resident immune cells of the brain, have emerged as crucial regulators of synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse types during development is mediated by specialized microglia is unknown. Here, we show that GABA-receptive microglia selectively interact with inhibitory cortical synapses during a critical window of mouse postnatal development. GABA initiates a transcriptional synapse remodeling program within these specialized microglia, which in turn sculpt inhibitory connectivity without impacting excitatory synapses. Ablation of GABA
Identifiants
pubmed: 34233165
pii: S0092-8674(21)00753-4
doi: 10.1016/j.cell.2021.06.018
pmc: PMC9122259
mid: NIHMS1716062
pii:
doi:
Substances chimiques
Parvalbumins
0
Receptors, GABA-B
0
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4048-4063.e32Subventions
Organisme : NINDS NIH HHS
ID : P01 NS074972
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS072030
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH071679
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH121289
Pays : United States
Organisme : NIMH NIH HHS
ID : UG3 MH120096
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH071679
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS081297
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests B.S. serves on the SAB and is a minor shareholder of Annexon. G.F. is a founder of Regel. The other authors declare no competing interests.
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