Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress.

Acetaminophen / toxicity Animals Chemical and Drug Induced Liver Injury / etiology Chemical and Drug Induced Liver Injury, Chronic / metabolism Cytochrome P-450 CYP2E1 / genetics Isoflavones Liver Mice Oxidative Stress Phenols
CYP2E1 Glabridin Glycyrrhiza glabra hepatoprotective paracetamol-induced liver injury

Journal

Drug and chemical toxicology
ISSN: 1525-6014
Titre abrégé: Drug Chem Toxicol
Pays: United States
ID NLM: 7801723

Informations de publication

Date de publication:
Sep 2022
Historique:
pubmed: 9 7 2021
medline: 15 9 2022
entrez: 8 7 2021
Statut: ppublish

Résumé

CYP2E1 plays a crucial role in the bio-activation of toxic substances leading to liver damage. In this context, CYP2E1 converts paracetamol (PCM) to N-acetyl-p-benzoquinone imine (NAPQI), which is prone to cause hepatotoxicity. Hence, we aimed to explore the protective effect of glabridin on widely used PCM-induced liver injury model in the present study and, after that, correlated with the role of CYP2E1 toward its efficacy. Glabridin was isolated from

Identifiants

DOI: 10.1080/01480545.2021.1945004 PMID: 34233566
pubmed: 34233566
doi: 10.1080/01480545.2021.1945004
doi:

Substances chimiques

Isoflavones 0
Phenols 0
Acetaminophen 362O9ITL9D
Cytochrome P-450 CYP2E1 EC 1.14.13.-
glabridin HOC5567T41

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2352-2360

Auteurs

Shipra Bhatt (S)

PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

Ankita Sharma (A)

PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

Ashish Dogra (A)

PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

Priyanka Sharma (P)

Plant Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.

Amit Kumar (A)

Bio-Organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.

Pankul Kotwal (P)

PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

Swarnendu Bag (S)

Instrumentation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.
Proteomics Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.

Prashant Misra (P)

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.
Plant Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.

Gurdarshan Singh (G)

PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

Ajay Kumar (A)

PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

Payare Lal Sangwan (PL)

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.
Bio-Organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.

Utpal Nandi (U)

PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.
ORCID: 0000-0002-7868-0240

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Anilides › Acétanilides › Acétaminophène › Glabridin attenuates paracetamol-induced liver...
questionsmedicales.fr › Eucaryotes › Animaux › Glabridin attenuates paracetamol-induced liver...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Glabridin attenuates paracetamol-induced liver...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Lésions hépatiques chroniques d'origine chimique ou médicamenteuse › Glabridin attenuates paracetamol-induced liver...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-2 de cytochromes P450 › Cytochrome P-450 CYP2E1 › Glabridin attenuates paracetamol-induced liver...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Isoflavones › Glabridin attenuates paracetamol-induced liver...
questionsmedicales.fr › Système digestif › Foie › Glabridin attenuates paracetamol-induced liver...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Glabridin attenuates paracetamol-induced liver...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Glabridin attenuates paracetamol-induced liver...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Glabridin attenuates paracetamol-induced liver...