Sex differences in recovery of quality of life 12 months post-fracture in community-dwelling older adults: analyses of the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS).

Aged Australia / epidemiology Female Hip Fractures Humans Independent Living Male Osteoporotic Fractures Quality of Life Sex Characteristics
Aging Fractures Osteoporosis Quality of life Sex

Journal

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
ISSN: 1433-2965
Titre abrégé: Osteoporos Int
Pays: England
ID NLM: 9100105

Informations de publication

Date de publication:
Jan 2022
Historique:
received: 30 03 2021
accepted: 29 06 2021
pubmed: 9 7 2021
medline: 18 1 2022
entrez: 8 7 2021
Statut: ppublish

Résumé

In this study of 695 Australian older adults (aged ≥50 years), we found that men and women had a similar trajectory of health-related quality of life (HRQoL) recovery following fragility fracture at any skeletal site. These results provide us with critical knowledge that improves our understanding of health outcomes post-fracture. Mortality is higher in men than that in women following a fragility fracture, but it is unclear whether recovery of patient-reported outcomes such as health-related quality of life (HRQoL) differs between sexes. This study aimed to identify sex differences in HRQoL recovery 12 months post-fracture. Data were from the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS). Participants recruited to AusICUROS were adults aged ≥50 years who sustained a fragility fracture. HRQoL was measured using the EQ-5D-3L at three time-points post-fracture: within 2 weeks (including pre-fracture recall) and at 4 and 12 months. Multivariate logistic regression analyses were undertaken, adjusting for confounders including age, education, income, and healthcare utilization post-fracture. Overall, 695 AusICUROS participants (536 women, 77.1%) were eligible for analysis with fractures at the hip (n = 150), distal forearm (n = 261), vertebrae (n = 61), humerus (n = 52), and other skeletal sites (n = 171). At the time of fracture, men were younger, reported a higher income, and were more likely to be employed, compared with women. For all fracture sites combined, there were no differences between men and women in recovery to pre-fracture HRQoL at 12-month follow-up (adjusted OR = 1.09; 95% CI: 0.75-1.61). When stratified by fracture site, no significant sex differences were seen for hip (OR = 1.02; 95% CI: 0.42-2.52), distal forearm (OR = 1.60; 95% CI: 0.68-3.78), vertebral (OR = 2.28; 95% CI: 0.61-8.48), humeral (OR = 1.62; 95% CI: 0.16-9.99), and other fractures (OR = 1.00; 95% CI: 0.44-2.26). Community-dwelling men and women who survived the 12 months following fragility fracture had a similar trajectory of HRQoL recovery at any skeletal site.

Identifiants

DOI: 10.1007/s00198-021-06058-3 PMID: 34235548
pubmed: 34235548
doi: 10.1007/s00198-021-06058-3
pii: 10.1007/s00198-021-06058-3
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

67-75

Subventions

Organisme : National Health and Medical Research Council
ID : 1151089
Organisme : National Health and Medical Research Council
ID : 628422

Informations de copyright

© 2021. International Osteoporosis Foundation and National Osteoporosis Foundation.

Références

Strom O, Borgstrom F, Kanis JA, Compston J, Cooper C, McCloskey EV, Jonsson B (2011) Osteoporosis: burden, health care provision and opportunities in the EU: a report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos 6:59–155
pubmed: 22886101 doi: 10.1007/s11657-011-0060-1
Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A (2001) The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int 12:417–427
pubmed: 11444092 doi: 10.1007/s001980170112
Dempster DW (2011) Osteoporosis and the burden of osteoporosis-related fractures. Am J Manag Care 17:S164
pubmed: 21761955
Borgstrom F, Karlsson L, Ortsater G et al (2020) Fragility fractures in Europe: burden, management and opportunities. Arch Osteoporos 15:59
pubmed: 32306163 pmcid: 7166207 doi: 10.1007/s11657-020-0706-y
Pisani P, Renna MD, Conversano F, Casciaro E, Di Paola M, Quarta E, Muratore M, Casciaro S (2016) Major osteoporotic fragility fractures: risk factor updates and societal impact. World J Orthop 7:171–181
pubmed: 27004165 pmcid: 4794536 doi: 10.5312/wjo.v7.i3.171
Svedbom A, Borgstom F, Hernlund E et al (2018) Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures-results from the ICUROS. Osteoporos Int 29:557–566
pubmed: 29230511 doi: 10.1007/s00198-017-4317-4
Abimanyi-Ochom J, Watts JJ, Borgstrom F et al (2015) Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS). Osteoporos Int 26:1781–1790
pubmed: 25792491 pmcid: 4468793 doi: 10.1007/s00198-015-3088-z
Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR (2009) Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA 301:513–521
pubmed: 19190316 doi: 10.1001/jama.2009.50
Cauley JA, Hochberg MC, Lui LY, Palermo L, Ensrud KE, Hillier TA, Nevitt MC, Cummings SR (2007) Long-term risk of incident vertebral fractures. JAMA 298:2761–2767
pubmed: 18165669 doi: 10.1001/jama.298.23.2761
Kumar V, Abbas AK, Aster JC (2015) Robbins and Cotran pathologic basis of disease. Elsevier/Saunders, Philadelphia, PA
Hannan MT, Felson DT, Dawson-Hughes B, Tucker KL, Cupples LA, Wilson PW, Kiel DP (2000) Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res 15:710–720
pubmed: 10780863 doi: 10.1359/jbmr.2000.15.4.710
Sigurdsson G, Aspelund T, Chang M, Jonsdottir B, Sigurdsson S, Eiriksdottir G, Gudmundsson A, Harris TB, Gudnason V, Lang TF (2006) Increasing sex difference in bone strength in old age: the Age, Gene/Environment Susceptibility-Reykjavik study (AGES-REYKJAVIK). Bone 39:644–651
pubmed: 16790372 doi: 10.1016/j.bone.2006.03.020
Curtis EM, van der Velde R, Moon RJ, van den Bergh JP, Geusens P, de Vries F, van Staa TP, Cooper C, Harvey NC (2016) Epidemiology of fractures in the United Kingdom 1988-2012: variation with age, sex, geography, ethnicity and socioeconomic status. Bone 87:19–26
pubmed: 26968752 pmcid: 4890652 doi: 10.1016/j.bone.2016.03.006
Kanis JA, Johnell O, Oden A, Sembo I, Redlund-Johnell I, Dawson A, De Laet C, Jonsson B (2000) Long-term risk of osteoporotic fracture in Malmo. Osteoporos Int 11:669–674
pubmed: 11095169 doi: 10.1007/s001980070064
van Staa TP, Dennison EM, Leufkens HG, Cooper C (2001) Epidemiology of fractures in England and Wales. Bone 29:517–522
pubmed: 11728921 doi: 10.1016/S8756-3282(01)00614-7
Amarilla-Donoso FJ, Lopez-Espuela F, Roncero-Martin R, Leal-Hernandez O, Puerto-Parejo LM, Aliaga-Vera I, Toribio-Felipe R, Lavado-Garcia JM (2020) Quality of life in elderly people after a hip fracture: a prospective study. Health Qual Life Outcomes 18:71
pubmed: 32171319 pmcid: 7071575 doi: 10.1186/s12955-020-01314-2
Sylliaas H, Thingstad P, Wyller TB, Helbostad J, Sletvold O, Bergland A (2012) Prognostic factors for self-rated function and perceived health in patient living at home three months after a hip fracture. Disabil Rehabil 34:1225–1231
pubmed: 22229943 doi: 10.3109/09638288.2011.643333
Van Son MAC, De Vries J, Zijlstra W, Roukema JA, Gosens T, Verhofstad MHJ, Den Oudsten BL (2017) Trajectories in quality of life of patients with a fracture of the distal radius or ankle using latent class analysis. Qual Life Res 26:3251–3265
pubmed: 28766080 pmcid: 5681973 doi: 10.1007/s11136-017-1670-x
Adachi JD, Loannidis G, Berger C, Joseph L, Papaioannou A, Pickard L, Papadimitropoulos EA, Hopman W, Poliquin S, Prior JC, Hanley DA, Olszynski WP, Anastassiades T, Brown JP, Murray T, Jackson SA, Tenenhouse A, Canadian Multicentre Osteoporosis Study (CaMos) Research Group (2001) The influence of osteoporotic fractures on health-related quality of life in community-dwelling men and women across Canada. Osteoporos Int 12:903–908
pubmed: 11804016 doi: 10.1007/s001980170017
Papaioannou A, Kennedy CC, Ioannidis G et al (2009) The impact of incident fractures on health-related quality of life: 5 years of data from the Canadian Multicentre Osteoporosis Study. Osteoporos Int 20:703–714
pubmed: 18802659 doi: 10.1007/s00198-008-0743-7
Mizrahi EH, Arad M, Fleissig Y, Adunsky A (2014) Gender differences in functional outcome of elderly hip fracture patients. Geriatr Gerontol Int 14:845–850
pubmed: 24279758 doi: 10.1111/ggi.12178
Di Monaco M, Castiglioni C, Vallero F, Di Monaco R, Tappero R (2012) Men recover ability to function less than women do: an observational study of 1094 subjects after hip fracture. Am J Phys Med Rehabil 91:309–315
pubmed: 22311061 doi: 10.1097/PHM.0b013e3182466162
Lahtinen A, Leppilahti J, Vähänikkilä H, Kujala S, Ristiniemi J, Jalovaara P (2020) No major differences in recovery after hip fracture between home-dwelling female and male patients. Scand J Surg 109:250–264
pubmed: 31088335 doi: 10.1177/1457496919847932
Beaupre LA, Carson JL, Noveck H, Magaziner J (2015) Recovery of walking ability and return to community living within 60 days of hip fracture does not differ between male and female survivors. J Am Geriatr Soc 63:1640–1644
pubmed: 26200232 pmcid: 4610808 doi: 10.1111/jgs.13535
Endo Y, Aharonoff GB, Zuckerman JD, Egol KA, Koval KJ (2005) Gender differences in patients with hip fracture: a greater risk of morbidity and mortality in men. J Orthop Trauma 19:29–35
pubmed: 15668581 doi: 10.1097/00005131-200501000-00006
Hawkes WG, Wehren L, Orwig D, Hebel JR, Magaziner J (2006) Gender differences in functioning after hip fracture. J Gerontol A Biol Sci Med Sci 61:495–499
pubmed: 16720747 doi: 10.1093/gerona/61.5.495
Chou FP, Chang HC, Yeh CC, Wu CH, Cherng YG, Chen TL, Liao CC (2020) Sex differences in fracture outcomes within Taiwan population: a nationwide matched study. PLoS One 15:e0231374
pubmed: 32271850 pmcid: 7144979 doi: 10.1371/journal.pone.0231374
Szende A, Oppe M, Devlin NJ, EuroQol Group (2007) EQ-5D value sets : inventory, comparative review, and user guide. Springer, Dordrecht
Viney R, Norman R, King MT, Cronin P, Street DJ, Knox S, Ratcliffe J (2011) Time trade-off derived EQ-5D weights for Australia. Value Health 14:928–936
pubmed: 21914515 doi: 10.1016/j.jval.2011.04.009
Roset M, Badia X, Mayo NE (1999) Sample size calculations in studies using the EuroQol 5D. Qual Life Res 8:539–549
pubmed: 10548869 doi: 10.1023/A:1008973731515
Si L, Winzenberg T, De Graaff B, Palmer A (2014) A systematic review and meta-analysis of utility-based quality of life for osteoporosis-related conditions. Osteoporos Int 25:1987–1997
pubmed: 24562840
Gjertsen JE, Baste V, Fevang JM, Furnes O, Engesaeter LB (2016) Quality of life following hip fractures: results from the Norwegian hip fracture register. BMC Musculoskelet Disord 17:265
pubmed: 27387741 pmcid: 4936302 doi: 10.1186/s12891-016-1111-y
Dyer SM, Crotty M, Fairhall N, Magaziner J, Beaupre LA, Cameron ID, Sherrington C (2016) A critical review of the long-term disability outcomes following hip fracture. BMC Geriatr 16:158
pubmed: 27590604 pmcid: 5010762 doi: 10.1186/s12877-016-0332-0
Cunningham TD, Di Pace BS, Ullal J (2014) Osteoporosis treatment disparities: a 6-year aggregate analysis from national survey data. Osteoporos Int 25:2199–2208
pubmed: 24899101 doi: 10.1007/s00198-014-2747-9
van der Velde RY, Wyers CE, Teesselink E, Geusens P, van den Bergh JPW, de Vries F, Cooper C, Harvey NC, van Staa TP (2017) Trends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: variation by age, sex, geographic location and ethnicity. Bone 94:50–55
pubmed: 27742502 doi: 10.1016/j.bone.2016.10.013
Balasubramanian A, Tosi LL, Lane JM, Dirschl DR, Ho PR, O’Malley CD (2014) Declining rates of osteoporosis management following fragility fractures in the U.S., 2000 through 2009. J Bone Joint Surg Am 96:e52
pubmed: 24695929 doi: 10.2106/JBJS.L.01781
Nakayama A, Major G, Holliday E, Attia J, Bogduk N (2016) Evidence of effectiveness of a fracture liaison service to reduce the re-fracture rate. Osteoporos Int 27:873–879
pubmed: 26650377 doi: 10.1007/s00198-015-3443-0
Talevski J, Sanders KM, Duque G, Connaughton C, Beauchamp A, Green D, Millar L, Brennan-Olsen SL (2019) Effect of clinical care pathways on quality of life and physical function after fragility fracture: a meta-analysis. J Am Med Dir Assoc 20(926):e921–926 e911
Talevski J, Sanders KM, Busija L, Beauchamp A, Duque G, Borgström F, Kanis JA, Svedbom A, Connaughton C, Stuart AL, Brennan-Olsen SL (2021) Health service use and quality of life recovery 12 months following major osteoporotic fracture: latent class analyses of the International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS). J Bone Miner Res 36:252–261
pubmed: 32960460 doi: 10.1002/jbmr.4181
Talevski J, Sanders KM, Busija L, Beauchamp A, Duque G, Borgstrom F, Kanis JA, Svedbom A, Stuart AL, Brennan-Olsen S (2021) Health service use pathways associated with recovery of quality of life at 12-months for individual fracture sites: analyses of the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS). Bone 144:115805
pubmed: 33321265 doi: 10.1016/j.bone.2020.115805
Kaufman JM, Reginster JY, Boonen S, Brandi ML, Cooper C, Dere W, Devogelaer JP, Diez-Perez A, Kanis JA, McCloskey E, Mitlak B, Orwoll E, Ringe JD, Weryha G, Rizzoli R (2013) Treatment of osteoporosis in men. Bone 53:134–144
pubmed: 23201268 doi: 10.1016/j.bone.2012.11.018
Lee KH, Xu H, Wu B (2020) Gender differences in quality of life among community-dwelling older adults in low- and middle-income countries: results from the Study on global AGEing and adult health (SAGE). BMC Public Health 20:114
pubmed: 31992264 pmcid: 6988191 doi: 10.1186/s12889-020-8212-0
Hutchinson AF, Graco M, Rasekaba TM, Parikh S, Berlowitz DJ, Lim WK (2015) Relationship between health-related quality of life, comorbidities and acute health care utilisation, in adults with chronic conditions. Health Qual Life Outcomes 13:69
pubmed: 26021834 pmcid: 4446844 doi: 10.1186/s12955-015-0260-2
Wilson IB, Cleary PD (1995) Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes JAMA 273:59–65
pubmed: 7996652
Szende A, Janssen B, Cabases J (2014) Self-reported population health: an international perspective based on EQ-5D. Springer Netherlands Dordrecht,

Auteurs

J Talevski (J)

Department of Medicine-Western Health, WCHRE Building, The University of Melbourne, 176 Furlong Road, St Albans, Victoria, VIC, 3021, Australia. jason.talevski@student.unimelb.edu.au.
Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, Victoria, Australia. jason.talevski@student.unimelb.edu.au.
ORCID: 0000-0001-9180-8758

K M Sanders (KM)

Department of Medicine-Western Health, WCHRE Building, The University of Melbourne, 176 Furlong Road, St Albans, Victoria, VIC, 3021, Australia.
Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, Victoria, Australia.
School of Health and Social Development, Deakin University, Geelong, Victoria, Australia.

J J Watts (JJ)

School of Health and Social Development, Deakin University, Geelong, Victoria, Australia.
Institute for Health Transformation, Deakin University, Geelong, Victoria, Australia.

G C Nicholson (GC)

Department of Medicine-Western Health, WCHRE Building, The University of Melbourne, 176 Furlong Road, St Albans, Victoria, VIC, 3021, Australia.
Rural Clinical School, The University of Queensland, Toowoomba, Australia.

E Seeman (E)

Departments of Endocrinology and Medicine, The University of Melbourne/Austin Health, Heidelberg, Victoria, Australia.
Mary McKillip Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.

S Iuliano (S)

Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, Victoria, Australia.
Departments of Endocrinology and Medicine, The University of Melbourne/Austin Health, Heidelberg, Victoria, Australia.

R Prince (R)

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Medical School, Sir Charles Gardner Unit, The University Western Australia, Perth, Western Australia, Australia.

L March (L)

Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia.

T Winzenberg (T)

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

G Duque (G)

Department of Medicine-Western Health, WCHRE Building, The University of Melbourne, 176 Furlong Road, St Albans, Victoria, VIC, 3021, Australia.
Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, Victoria, Australia.

P R Ebeling (PR)

Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.

F Borgström (F)

Quantify Research, Stockholm, Sweden.
Department of Learning, Informatics, Management and Ethics, Medical Management Centre, Karolinska Institute, Stockholm, Sweden.

J A Kanis (JA)

Mary McKillip Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.
Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.

A L Stuart (AL)

The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine Deakin University, Geelong, Victoria, Australia.

A Beauchamp (A)

Department of Medicine-Western Health, WCHRE Building, The University of Melbourne, 176 Furlong Road, St Albans, Victoria, VIC, 3021, Australia.
Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, Victoria, Australia.
School of Rural Health, Monash University, Victoria, Australia.

S L Brennan-Olsen (SL)

Department of Medicine-Western Health, WCHRE Building, The University of Melbourne, 176 Furlong Road, St Albans, Victoria, VIC, 3021, Australia.
Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, Victoria, Australia.
School of Health and Social Development, Deakin University, Geelong, Victoria, Australia.
Institute for Health Transformation, Deakin University, Geelong, Victoria, Australia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sex differences in recovery of quality of life...
questionsmedicales.fr › Régions géographiques › Océanie › Australasie › Australie › Sex differences in recovery of quality of life...
questionsmedicales.fr › Plaies et blessures › Traumatismes de la jambe › Fractures du fémur › Fractures de la hanche › Sex differences in recovery of quality of life...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sex differences in recovery of quality of life...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › Caractéristiques de l'habitat › Vie autonome › Sex differences in recovery of quality of life...
questionsmedicales.fr › Plaies et blessures › Fractures osseuses › Fractures ostéoporotiques › Sex differences in recovery of quality of life...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Sex differences in recovery of quality of life...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Sex differences in recovery of quality of life...