Development of a human antibody fragment directed against the alpha folate receptor as a promising molecule for targeted application.
Non-small-cell lung cancer (NSCLC)
alpha folate receptor (FRα)
phage display
targeted therapy
variable domain of a heavy-chain (VH)
Journal
Drug delivery
ISSN: 1521-0464
Titre abrégé: Drug Deliv
Pays: England
ID NLM: 9417471
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
entrez:
8
7
2021
pubmed:
9
7
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Alpha folate receptor (FRα) is currently under investigation as a target for the treatment of patients with non-small-cell lung cancer (NSCLC), since it is highly expressed in tumor cells but is largely absent in normal tissue. In this study, a novel human variable domain of a heavy-chain (VH) antibody fragment specific to FRα was enriched and selected by phage bio-planning. The positive phage clone (3A102 VH) specifically bound to FRα and also cross-reacted with FRβ, as tested by ELISA. Clone 3A102 VH was then successfully expressed as a soluble protein in an
Identifiants
pubmed: 34236266
doi: 10.1080/10717544.2021.1943055
pmc: PMC8274507
doi:
Substances chimiques
Folate Receptor 1
0
Immunoglobulin Fragments
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1443-1454Références
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