Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity.
Animals
Cell Differentiation
Cells, Cultured
Humans
Interleukin-17
/ metabolism
Lymphocyte Activation
Male
Mice
Mice, Inbred C57BL
Psoriasis
/ metabolism
Severity of Illness Index
Skin
/ metabolism
Sodium
/ analysis
Sodium Chloride
/ metabolism
Spectrophotometry, Atomic
Spectrum Analysis
Th17 Cells
/ immunology
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
04
09
2020
revised:
14
05
2021
accepted:
03
06
2021
pubmed:
9
7
2021
medline:
15
1
2022
entrez:
8
7
2021
Statut:
ppublish
Résumé
Sodium can accumulate in the skin at concentrations exceeding serum levels. A high sodium environment can lead to pathogenic T helper 17 cell expansion. Psoriasis is a chronic inflammatory skin disease in which IL-17‒producing T helper 17 cells play a crucial role. In an observational study, we measured skin sodium content in patients with psoriasis and in age-matched healthy controls by Sodium-23 magnetic resonance imaging. Patients with PASI > 5 showed significantly higher sodium and water content in the skin but not in other tissues than those with lower PASI or healthy controls. Skin sodium concentrations measured by Sodium-23 spectroscopy or by atomic absorption spectrometry in ashed-skin biopsies verified the findings with Sodium-23 magnetic resonance imaging. In vitro T helper 17 cell differentiation of naive CD4
Identifiants
pubmed: 34237339
pii: S0022-202X(21)01423-8
doi: 10.1016/j.jid.2021.06.013
pii:
doi:
Substances chimiques
Interleukin-17
0
Sodium Chloride
451W47IQ8X
Sodium
9NEZ333N27
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
166-178.e8Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.