Management of Congenital Long-QT Syndrome: Commentary From the Experts.

Adrenergic beta-Antagonists / therapeutic use Consensus Diagnostic Techniques, Cardiovascular Disease Management Humans Long QT Syndrome / congenital
defibrillators, implantable genetic testing knowledge long-QT syndrome politics

Journal

Circulation. Arrhythmia and electrophysiology
ISSN: 1941-3084
Titre abrégé: Circ Arrhythm Electrophysiol
Pays: United States
ID NLM: 101474365

Informations de publication

Date de publication:
07 2021
Historique:
pubmed: 10 7 2021
medline: 28 12 2021
entrez: 9 7 2021
Statut: ppublish

Résumé

While published guidelines are useful in the care of patients with long-QT syndrome, it can be difficult to decide how to apply the guidelines to individual patients, particularly those with intermediate risk. We explored the diversity of opinion among 24 clinicians with expertise in long-QT syndrome. Experts from various regions and institutions were presented with 4 challenging clinical scenarios and asked to provide commentary emphasizing why they would make their treatment recommendations. All 24 authors were asked to vote on case-specific questions so as to demonstrate the degree of consensus or divergence of opinion. Of 24 authors, 23 voted and 1 abstained. Details of voting results with commentary are presented. There was consensus on several key points, particularly on the importance of the diagnostic evaluation and of β-blocker use. There was diversity of opinion about the appropriate use of other therapeutic measures in intermediate-risk individuals. Significant gaps in knowledge were identified.

Identifiants

DOI: 10.1161/CIRCEP.120.009726 PMID: 34238011 PMC: PMC8301722
pubmed: 34238011
doi: 10.1161/CIRCEP.120.009726
pmc: PMC8301722
mid: NIHMS1715303
doi:

Substances chimiques

Adrenergic beta-Antagonists 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e009726

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL111314
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128598
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139738
Pays : United States

Références

Heart Rhythm. 2019 Aug;16(8):1141-1148
pubmed: 31075442
Heart Rhythm. 2013 Dec;10(12):1932-63
pubmed: 24011539
Circulation. 2020 Dec 22;142(25):2405-2415
pubmed: 33073610
N Engl J Med. 2003 May 8;348(19):1866-74
pubmed: 12736279
Heart Rhythm. 2004 May;1(1):60-4
pubmed: 15851119
Circulation. 1995 Nov 15;92(10):2929-34
pubmed: 7586261
Am J Cardiol. 2008 Oct 1;102(7):871-4
pubmed: 18805113
Circulation. 2000 Feb 15;101(6):616-23
pubmed: 10673253
Circulation. 2001 Jul 31;104(5):557-62
pubmed: 11479253
Heart Rhythm. 2017 Jan;14(1):e41-e44
pubmed: 27659101
J Interv Card Electrophysiol. 2016 Nov;47(2):163-170
pubmed: 27394160
Circulation. 2003 Feb 18;107(6):838-44
pubmed: 12591753
Circulation. 2007 May 22;115(20):2613-20
pubmed: 17502575
Heart Rhythm. 2020 Feb;17(2):341-348
pubmed: 31400520
Hypertension. 2021 May 5;77(5):1539-1548
pubmed: 33719510
Circulation. 2010 Sep 28;122(13):1272-82
pubmed: 20837891
JAMA. 2006 Sep 13;296(10):1249-54
pubmed: 16968849
Europace. 2019 Feb 1;21(2):339-346
pubmed: 29947754
Circulation. 2018 Feb 6;137(6):619-630
pubmed: 29431662
Circulation. 2001 Jan 2;103(1):89-95
pubmed: 11136691
Heart Rhythm. 2008 Jan;5(1):11-8
pubmed: 18180017
Am J Obstet Gynecol. 2020 Mar;222(3):263.e1-263.e11
pubmed: 31520628
Circulation. 2009 Jan 20;119(2):215-21
pubmed: 19118258
J Am Coll Cardiol. 2009 Nov 24;54(22):2052-62
pubmed: 19926013
J Am Coll Cardiol. 2018 Apr 17;71(15):1663-1671
pubmed: 29650123
Heart Rhythm. 2012 Dec;9(12):1977-82
pubmed: 22885918
Circ Arrhythm Electrophysiol. 2010 Apr;3(2):120-5
pubmed: 20071715
Acta Cardiol. 2005 Aug;60(4):387-93
pubmed: 16128371
JAMA. 2004 Sep 15;292(11):1341-4
pubmed: 15367556
Circulation. 2008 Apr 29;117(17):2192-201
pubmed: 18427134
J Am Coll Cardiol. 2012 Nov 13;60(20):2092-9
pubmed: 23083782
Front Cardiovasc Med. 2019 Mar 26;6:27
pubmed: 30972341
Circulation. 2016 Sep 20;134(12):872-82
pubmed: 27566755
Am J Cardiol. 1999 Dec 15;84(12):1406-11
pubmed: 10606113
Ann Noninvasive Electrocardiol. 2018 May;23(3):e12537
pubmed: 29504689
J Am Coll Cardiol. 1995 Dec;26(7):1685-91
pubmed: 7594104
Circ Arrhythm Electrophysiol. 2018 Jul;11(7):e005918
pubmed: 30012873
Heart Rhythm. 2012 Jun;9(6):901-8
pubmed: 22300664
Eur Heart J. 2007 Dec;28(23):2944-9
pubmed: 17947213
J Am Coll Cardiol. 2014 Sep 30;64(13):1352-8
pubmed: 25257637
Hypertension. 2020 Oct;76(4):1263-1279
pubmed: 32829669
J Am Coll Cardiol. 2015 Dec 1;66(21):2424-2428
pubmed: 26542662
Circulation. 2004 Apr 20;109(15):1826-33
pubmed: 15051644
Circulation. 2018 Sep 25;138(13):e272-e391
pubmed: 29084731
Circ Arrhythm Electrophysiol. 2019 May;12(5):e007280
pubmed: 31006312
J Clin Invest. 2008 Jul;118(7):2552-61
pubmed: 18551196
J Am Coll Cardiol. 2003 Jul 2;42(1):103-9
pubmed: 12849668
J Cardiovasc Electrophysiol. 2010 Aug 1;21(8):893-901
pubmed: 20233272

Auteurs

Elizabeth S Kaufman (ES)

Heart & Vascular Center, MetroHealth Campus, Case Western Reserve University, Cleveland, OH (E.S.K.).

Lee L Eckhardt (LL)

Cellular and Molecular Arrhythmia Research Program, Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison (L.L.E.).

Michael J Ackerman (MJ)

Departments of Cardiovascular Medicine (M.J.A.), Mayo Clinic, Rochester, MN.
Pediatric and Adolescent Medicine (M.J.A.), Mayo Clinic, Rochester, MN.
Molecular Pharmacology and Experimental Therapeutics (M.J.A.), Mayo Clinic, Rochester, MN.

Peter F Aziz (PF)

Pediatric Electrophysiology and Inherited Arrhythmia Clinic, Cleveland Clinic Children's, OH (P.F.A.).

Elijah R Behr (ER)

Cardiovascular Clinical Academic Group, Institute of Molecular and Clinical Sciences, St George's, University of London, St George's University Hospitals NHS Foundation Trust, United Kingdom (E.R.B.).
ERN GUARDHEART members of the European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (http://guardheart.ern-net.eu) (E.R.B., S.G.P., E.S.-B., P.J.S., A.A.M.W.).

Marina Cerrone (M)

Inherited Arrhythmias Clinic, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine (M.C.).

Mina K Chung (MK)

Heart, Vascular and Thoracic Department, Department of Cardiovascular Medicine, Cleveland Clinic, OH (M.K.C.).

Michael J Cutler (MJ)

Intermountain Medical Center Heart Institute, Intermountain Medical Center, Murray, UT (M.J.C.).

Susan P Etheridge (SP)

Department of Pediatrics, Division of Pediatric Cardiology, University of Utah, Salt Lake City (S.P.E.).

Andrew D Krahn (AD)

Center for Cardiovascular Innovation, Division of Cardiology, University of British Columbia, Vancouver, Canada (A.D.K.).

Steven A Lubitz (SA)

Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.A.L.).

Marco V Perez (MV)

Stanford Center for Inherited Cardiovascular Diseases, Stanford University, Palo Alto, CA (M.V.P.).

Silvia G Priori (SG)

ERN GUARDHEART members of the European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (http://guardheart.ern-net.eu) (E.R.B., S.G.P., E.S.-B., P.J.S., A.A.M.W.).
Istituti Clinici Scientifici Maugeri, Pavia, Italy (S.G.P.).
Department of Molecular Medicine, University of Pavia, Italy (S.G.P.).

Jason D Roberts (JD)

Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada (J.D.R.).

Dan M Roden (DM)

Senior Vice-President for Personalized Medicine, Vanderbilt University Medical Center, Nashville, TN (D.M.R.).

Eric Schulze-Bahr (E)

ERN GUARDHEART members of the European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (http://guardheart.ern-net.eu) (E.R.B., S.G.P., E.S.-B., P.J.S., A.A.M.W.).
Institute for Genetics of Heart Diseases, University Hospital Münster, Germany (E.S.-B.).

Peter J Schwartz (PJ)

ERN GUARDHEART members of the European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (http://guardheart.ern-net.eu) (E.R.B., S.G.P., E.S.-B., P.J.S., A.A.M.W.).
Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy (P.J.S.).

Wataru Shimizu (W)

Department of Cardiovascular Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (W.S.).

M Benjamin Shoemaker (MB)

Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S.).

Raymond W Sy (RW)

Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, Australia (R.W.S.).
Sydney Medical School, University of Sydney, NSW, Australia (R.W.S.).

Jeffrey A Towbin (JA)

Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis (J.A.T.).

Sami Viskin (S)

Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Israel (S.V.).

Arthur A M Wilde (A)

ERN GUARDHEART members of the European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (http://guardheart.ern-net.eu) (E.R.B., S.G.P., E.S.-B., P.J.S., A.A.M.W.).
Department of Clinical and Experimental Cardiology, University of Amsterdam Heart Center, the Netherlands (A.A.M.W.).
Department of Clinical and Experimental Cardiology, Amsterdam, the Netherlands (A.A.M.W.).

Wojciech Zareba (W)

Clinical Cardiovascular Research Center, University of Rochester Medical Center, NY (W.Z.).

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Antagonistes adrénergiques › Antagonistes bêta-adrénergiques › Management of Congenital Long-QT Syndrome:...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Pensée (activité mentale) › Prise de décision › Consensus › Management of Congenital Long-QT Syndrome:...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic cardiovasculaire › Management of Congenital Long-QT Syndrome:...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Prise en charge de la maladie › Management of Congenital Long-QT Syndrome:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Management of Congenital Long-QT Syndrome:...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Syndrome du QT long › Management of Congenital Long-QT Syndrome:...