Is there a hypothalamic basis for anorexia nervosa?
Animal models
Anorexia nervosa
Arcuate nucleus
Brain imaging
GWAS
Neuroendocrine agents
Peripheral sensors
Journal
Handbook of clinical neurology
ISSN: 0072-9752
Titre abrégé: Handb Clin Neurol
Pays: Netherlands
ID NLM: 0166161
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
9
7
2021
pubmed:
10
7
2021
medline:
29
7
2021
Statut:
ppublish
Résumé
The hypothalamus has long been known to control food intake and energy metabolism through a complex network of primary and secondary neurons and glial cells. Anorexia nervosa being a complex disorder characterized by abnormal feeding behavior and food aversion, it is thus quite surprising that not much is known concerning potential hypothalamic modifications in this disorder. In this chapter, we review the recent advances in the fields of genetics, epigenetics, structural and functional imaging, and brain connectivity, as well as neuroendocrine findings and emerging animal models, which have begun to unravel the importance of hypothalamic adaptive processes to our understanding of the pathology of eating disorders.
Identifiants
pubmed: 34238474
pii: B978-0-12-820683-6.00030-0
doi: 10.1016/B978-0-12-820683-6.00030-0
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
405-424Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.