Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility.
Prdm9
chromosome-autonomous asynapsis
hybrid sterility
meiotic recombination
meiotic sex chromosome inactivation
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
19
04
2021
revised:
08
06
2021
accepted:
10
06
2021
pubmed:
10
7
2021
medline:
11
3
2022
entrez:
9
7
2021
Statut:
ppublish
Résumé
Hybrid sterility is a critical step in the evolution of reproductive barriers between diverging taxa during the process of speciation. Recent studies of young subspecies of the house mouse revealed a multigenic nature and frequent polymorphism of hybrid sterility genes as well as the recurrent engagement of the meiosis-specific gene PR domain-containing 9 (Prdm9) and X-linked loci. Prdm9-controlled hybrid sterility is essentially chromosomal in nature, conditioned by the sequence divergence between subspecies. Depending on the Prdm9 interallelic interactions and the X-linked Hstx2 locus, the same homologs either regularly recombine and synapse, or show impaired DNA DSB repair, asynapsis, and early meiotic arrest. Thus, Prdm9-dependent hybrid sterility points to incompatibilities affecting meiotic recombination as a possible mechanism of reproductive isolation between (sub)species.
Identifiants
pubmed: 34238593
pii: S0168-9525(21)00164-5
doi: 10.1016/j.tig.2021.06.008
pii:
doi:
Substances chimiques
Histone-Lysine N-Methyltransferase
EC 2.1.1.43
prdm9 protein, mouse
EC 2.1.1.43
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1095-1108Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests None declared by authors.