A simulation study investigating potential diffusion-based MRI signatures of microstrokes.

Diffusion Magnetic Resonance Imaging / methods Stroke / diagnostic imaging Tomography, Optical Coherence

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
09 07 2021
Historique:
received: 27 07 2020
accepted: 22 06 2021
entrez: 10 7 2021
pubmed: 11 7 2021
medline: 9 11 2021
Statut: epublish

Résumé

Recent studies suggested that cerebrovascular micro-occlusions, i.e. microstokes, could lead to ischemic tissue infarctions and cognitive deficits. Due to their small size, identifying measurable biomarkers of these microvascular lesions remains a major challenge. This work aims to simulate potential MRI signatures combining arterial spin labeling (ASL) and multi-directional diffusion-weighted imaging (DWI). Driving our hypothesis are recent observations demonstrating a radial reorientation of microvasculature around the micro-infarction locus during recovery in mice. Synthetic capillary beds, randomly- and radially-oriented, and optical coherence tomography (OCT) angiograms, acquired in the barrel cortex of mice (n = 5) before and after inducing targeted photothrombosis, were analyzed. Computational vascular graphs combined with a 3D Monte-Carlo simulator were used to characterize the magnetic resonance (MR) response, encompassing the effects of magnetic field perturbations caused by deoxyhemoglobin, and the advection and diffusion of the nuclear spins. We quantified the minimal intravoxel signal loss ratio when applying multiple gradient directions, at varying sequence parameters with and without ASL. With ASL, our results demonstrate a significant difference (p < 0.05) between the signal-ratios computed at baseline and 3 weeks after photothrombosis. The statistical power further increased (p < 0.005) using angiograms measured at week 4. Without ASL, no reliable signal change was found. We found that higher ratios, and accordingly improved significance, were achieved at lower magnetic field strengths (e.g., B0 = 3T) and shorter echo time TE (< 16 ms). Our simulations suggest that microstrokes might be characterized through ASL-DWI sequence, providing necessary insights for posterior experimental validations, and ultimately, future translational trials.

Identifiants

DOI: 10.1038/s41598-021-93503-2 PMID: 34244549 PMC: PMC8271016
pubmed: 34244549
doi: 10.1038/s41598-021-93503-2
pii: 10.1038/s41598-021-93503-2
pmc: PMC8271016
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

14229

Subventions

Organisme : CIHR
ID : 299166
Pays : Canada

Informations de copyright

© 2021. The Author(s).

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Auteurs

Rafat Damseh (R)

Laboratory of Optical and Molecular Imaging, École Polytechnique de Montréal, 2900 Edouard Montpetit Blvd, Montreal, QC, H3T 1J4, Canada. rafat.damseh@polymtl.ca.
Athinoula A. Martinos Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA. rafat.damseh@polymtl.ca.
Montreal Heart Institute, 5000 Rue Bélanger, Montreal, QC, H1T 1C8, Canada. rafat.damseh@polymtl.ca.

Yuankang Lu (Y)

Laboratory of Optical and Molecular Imaging, École Polytechnique de Montréal, 2900 Edouard Montpetit Blvd, Montreal, QC, H3T 1J4, Canada.
Montreal Heart Institute, 5000 Rue Bélanger, Montreal, QC, H1T 1C8, Canada.

Xuecong Lu (X)

Laboratory of Optical and Molecular Imaging, École Polytechnique de Montréal, 2900 Edouard Montpetit Blvd, Montreal, QC, H3T 1J4, Canada.
Montreal Heart Institute, 5000 Rue Bélanger, Montreal, QC, H1T 1C8, Canada.

Cong Zhang (C)

Montreal Heart Institute, 5000 Rue Bélanger, Montreal, QC, H1T 1C8, Canada.
Université de Montreal, 2900 Edouard Montpetit Blvd, Montreal, QC, H3T 1J4, Canada.

Paul J Marchand (PJ)

Laboratory of Optical and Molecular Imaging, École Polytechnique de Montréal, 2900 Edouard Montpetit Blvd, Montreal, QC, H3T 1J4, Canada.
Montreal Heart Institute, 5000 Rue Bélanger, Montreal, QC, H1T 1C8, Canada.

Denis Corbin (D)

Laboratory of Optical and Molecular Imaging, École Polytechnique de Montréal, 2900 Edouard Montpetit Blvd, Montreal, QC, H3T 1J4, Canada.

Philippe Pouliot (P)

Laboratory of Optical and Molecular Imaging, École Polytechnique de Montréal, 2900 Edouard Montpetit Blvd, Montreal, QC, H3T 1J4, Canada.
Montreal Heart Institute, 5000 Rue Bélanger, Montreal, QC, H1T 1C8, Canada.

Farida Cheriet (F)

Department of Computer and Software Engineering, École Polytechnique de Montréal, 2900 Edouard Montpetit Blvd, Montreal, QC, H3T 1J4, Canada.

Frederic Lesage (F)

Laboratory of Optical and Molecular Imaging, École Polytechnique de Montréal, 2900 Edouard Montpetit Blvd, Montreal, QC, H3T 1J4, Canada.
Montreal Heart Institute, 5000 Rue Bélanger, Montreal, QC, H1T 1C8, Canada.

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Classifications MeSH

questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Imagerie par résonance magnétique de diffusion › A simulation study investigating potential...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › A simulation study investigating potential...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Tomographie optique › Tomographie par cohérence optique › A simulation study investigating potential...