Heritability of quantitative autism spectrum traits in adults: A family-based study.
adult
autism spectrum disorder
family studies
heritability
phenotype
quantitative trait
Journal
Autism research : official journal of the International Society for Autism Research
ISSN: 1939-3806
Titre abrégé: Autism Res
Pays: United States
ID NLM: 101461858
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
27
05
2021
received:
05
03
2021
accepted:
06
06
2021
pubmed:
11
7
2021
medline:
13
8
2021
entrez:
10
7
2021
Statut:
ppublish
Résumé
Autism spectrum disorder (ASD) comprises a multi-dimensional set of quantitative behavioral traits expressed along a continuum in autistic and neurotypical individuals. ASD diagnosis-a dichotomous trait-is known to be highly heritable and has been used as the phenotype for most ASD genetic studies. But less is known about the heritability of autism spectrum quantitative traits, especially in adults, an important prerequisite for gene discovery. We sought to measure the heritability of many autism-relevant quantitative traits in adults high in autism spectrum traits and their extended family members. Among adults high in autism spectrum traits (n = 158) and their extended family members (n = 245), we calculated univariate and bivariate heritability estimates for 19 autism spectrum traits across several behavioral domains. We found nearly all tested autism spectrum quantitative traits to be significantly heritable (h
Identifiants
pubmed: 34245229
doi: 10.1002/aur.2571
pmc: PMC8596390
mid: NIHMS1751886
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1543-1553Subventions
Organisme : NIMH NIH HHS
ID : F31 MH125539
Pays : United States
Organisme : NIMH NIH HHS
ID : F31MH125539
Pays : United States
Informations de copyright
© 2021 International Society for Autism Research and Wiley Periodicals LLC.
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