Skin hydration as a tool to control the distribution and molecular effects of intermediate polarity compounds in intact stratum corneum.
Conformation
Corneocytes
Extracellular lipids
Keratin filaments
Molecular mobility
Trimethoxy propane
solid-state NMR
Journal
Journal of colloid and interface science
ISSN: 1095-7103
Titre abrégé: J Colloid Interface Sci
Pays: United States
ID NLM: 0043125
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
21
04
2021
revised:
07
06
2021
accepted:
15
06
2021
pubmed:
11
7
2021
medline:
22
9
2021
entrez:
10
7
2021
Statut:
ppublish
Résumé
The barrier function of the skin is mainly assured by its outermost layer, stratum corneum (SC), which consists of dead keratin-filled cells embedded in a lipid matrix. The skin is daily exposed to an environment with changing conditions in terms of hydration and different chemicals. Here we investigate how a molecule that has reasonable solubility in both hydrophobic and hydrophilic environments can be directed to certain regions in SC by changing the skin hydration. We use 1,2,3-trimethoxy propane (TMP) as a model substance and solid-state NMR on natural abundance
Identifiants
pubmed: 34246090
pii: S0021-9797(21)00971-1
doi: 10.1016/j.jcis.2021.06.097
pii:
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
874-885Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.