Inactivation of the Euchromatic Histone-Lysine
epigenomics
gene regulatory networks
histone methyltransferases
pancreatic carcinoma
tumor microenvironment
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
03
2021
accepted:
27
04
2021
entrez:
12
7
2021
pubmed:
13
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, painful disease with a 5-year survival rate of only 9%. Recent evidence indicates that distinct epigenomic landscapes underlie PDAC progression, identifying the H3K9me pathway as important to its pathobiology. Here, we delineate the role of Euchromatic Histone-lysine
Identifiants
pubmed: 34249932
doi: 10.3389/fcell.2021.681153
pmc: PMC8261250
doi:
Types de publication
Journal Article
Langues
eng
Pagination
681153Subventions
Organisme : NCI NIH HHS
ID : R01 CA226279
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA247898
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK052913
Pays : United States
Informations de copyright
Copyright © 2021 Urrutia, de Assuncao, Mathison, Salmonson, Kerketta, Zeighami, Stodola, Adsay, Pehlivanoglu, Dwinell, Zimmermann, Iovanna, Urrutia and Lomberk.
Déclaration de conflit d'intérêts
MBD is a co-founder and has ownership interests in Protein Foundry, LLC and Xlock Biosciences, LLC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cancer Discov. 2014 Jun;4(6):688-701
pubmed: 24694735
Future Med Chem. 2019 May;11(9):993-1014
pubmed: 31141392
Aging (Albany NY). 2019 Dec 4;11(23):11591-11608
pubmed: 31804189
Oncotarget. 2016 Sep 20;7(38):61136-61151
pubmed: 27531902
J Biol Chem. 2015 Oct 23;290(43):26088-102
pubmed: 26338712
Bioinformatics. 2019 Jul 15;35(14):i436-i445
pubmed: 31510660
Gut. 2016 Mar;65(3):476-86
pubmed: 25596178
Oncogene. 2014 Jun 5;33(23):2956-67
pubmed: 23851493
Minerva Gastroenterol Dietol. 2012 Dec;58(4):283-97
pubmed: 23207606
Front Cell Neurosci. 2019 Jul 09;13:300
pubmed: 31338024
Genes Dev. 2002 Jul 15;16(14):1779-91
pubmed: 12130538
Nat Rev Cancer. 2008 Jul;8(7):512-22
pubmed: 18574463
Mol Cell. 2017 Aug 17;67(4):550-565.e5
pubmed: 28803780
Mod Pathol. 2003 Oct;16(10):996-1006
pubmed: 14559982
Cancer Cell. 2018 Mar 12;33(3):512-526.e8
pubmed: 29533787
BMC Bioinformatics. 2014 Jun 27;15:224
pubmed: 24972667
Epigenetics. 2013 Jan;8(1):16-22
pubmed: 23257913
Nat Genet. 2017 Mar;49(3):367-376
pubmed: 28092686
Gut. 2019 Jul;68(7):1245-1258
pubmed: 30228219
Gut. 2019 Jul;68(7):1259-1270
pubmed: 30315093
Nucleic Acids Res. 2012 May;40(10):4288-97
pubmed: 22287627
Gastroenterology. 2012 May;142(5):1079-92
pubmed: 22406637
Genes Dev. 2012 Mar 1;26(5):439-44
pubmed: 22391448
Gastroenterology. 2013 Jun;144(6):1220-9
pubmed: 23622131
Nature. 2004 Nov 18;432(7015):307-15
pubmed: 15549092
Clin Cancer Res. 2015 Apr 15;21(8):1828-34
pubmed: 25878364
Genome Med. 2019 May 24;11(1):34
pubmed: 31126321
Cancer Cell. 2010 Nov 16;18(5):448-58
pubmed: 21075310
J Surg Oncol. 2013 Jan;107(1):8-14
pubmed: 22806689
Genes Dev. 2006 Nov 15;20(22):3089-103
pubmed: 17085482
Bioinformatics. 2014 Feb 15;30(4):523-30
pubmed: 24336805
Mol Cell. 2012 Jan 13;45(1):123-31
pubmed: 22178396
J Clin Invest. 2012 Feb;122(2):639-53
pubmed: 22232209
Dev Biol. 2002 Apr 15;244(2):305-18
pubmed: 11944939
Mol Cell. 2015 Sep 17;59(6):998-1010
pubmed: 26365379
Nat Commun. 2018 May 17;9(1):1978
pubmed: 29773832
Gastroenterology. 2018 Jul;155(1):194-209.e2
pubmed: 29604291
Mol Cell Biol. 2016 Nov 28;36(24):3033-3047
pubmed: 27697859
Carcinogenesis. 2015 Jul;36(7):730-8
pubmed: 25939753
EMBO J. 2013 Jan 9;32(1):45-59
pubmed: 23178591
Cancer Res. 2014 Jun 1;74(11):2913-21
pubmed: 24840647
Cancer Cell. 2007 Mar;11(3):291-302
pubmed: 17349585
Oncogene. 2007 May 14;26(22):3122-42
pubmed: 17496911
Gastroenterology. 2020 Aug;159(2):682-696.e13
pubmed: 32360551
Transl Res. 2019 Jun;208:105-118
pubmed: 30904443
World J Gastroenterol. 2012 Mar 28;18(12):1286-94
pubmed: 22493542
Nat Commun. 2018 May 25;9(1):2081
pubmed: 29802314
Genes Dev. 2011 Apr 15;25(8):781-8
pubmed: 21498567
Front Biosci (Landmark Ed). 2009 Jun 01;14:5013-30
pubmed: 19482602
J Clin Invest. 2012 Apr;122(4):1469-86
pubmed: 22406531
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5934-41
pubmed: 22421440
Trends Genet. 2003 Nov;19(11):629-39
pubmed: 14585615
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Cancer Genomics Proteomics. 2020 Nov-Dec;17(6):695-705
pubmed: 33099471
EMBO J. 2007 Jul 25;26(14):3346-59
pubmed: 17599069
Genes Dev. 2006 May 15;20(10):1218-49
pubmed: 16702400
Cancer Discov. 2018 May;8(5):537-555
pubmed: 29653955
Annu Rev Physiol. 2015;77:229-49
pubmed: 25386992
J Biol Chem. 2006 Jul 21;281(29):20120-8
pubmed: 16702210
Nat Commun. 2019 Aug 28;10(1):3875
pubmed: 31462645
Development. 2007 Mar;134(6):1151-60
pubmed: 17301087
Nat Commun. 2020 Jun 15;11(1):3018
pubmed: 32541668
Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6054-E6063
pubmed: 28698370
Cancer Cell. 2011 Jun 14;19(6):728-39
pubmed: 21665147
Skelet Muscle. 2016 May 27;6:22
pubmed: 27239264
PLoS One. 2013 Sep 17;8(9):e75311
pubmed: 24069400
Cell. 2009 Nov 25;139(5):871-90
pubmed: 19945376
J Hematol Oncol. 2020 Apr 21;13(1):39
pubmed: 32316968
PeerJ. 2019 Jul 19;7:e6994
pubmed: 31355053
Nat Rev Immunol. 2018 May;18(5):309-324
pubmed: 29379212
Cancer Cell. 2012 Sep 11;22(3):318-30
pubmed: 22975375
Mol Cancer Res. 2005 Nov;3(11):627-34
pubmed: 16317088
Gut. 2020 Apr;69(4):715-726
pubmed: 31300513
Nat Cell Biol. 2014 Mar;16(3):255-67
pubmed: 24561622
Genes Dev. 2001 Dec 15;15(24):3243-8
pubmed: 11751630
Cold Spring Harb Perspect Med. 2018 Sep 4;8(9):
pubmed: 29229669
Acta Pharmacol Sin. 2018 Oct;39(10):1553-1558
pubmed: 29620049
Cancer Cell. 2003 Dec;4(6):437-50
pubmed: 14706336
World J Gastroenterol. 2014 Oct 14;20(38):13833-41
pubmed: 25320520
Front Immunol. 2015 Sep 25;6:487
pubmed: 26441991
Cell Death Dis. 2013 Jun 27;4:e690
pubmed: 23807219
Nat Rev Mol Cell Biol. 2005 Nov;6(11):838-49
pubmed: 16261189
Biochem Cell Biol. 2016 Feb;94(1):26-32
pubmed: 26198080
ACS Chem Biol. 2012 Jul 20;7(7):1152-7
pubmed: 22536950