Angela J Mathison

Affiliations

Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, WI, USA.
Bioinformatics Research and Development Laboratory, and Precision Medicine Simulation Unit, GSPMC, Medical College of Wisconsin, Milwaukee, WI, USA.
Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.

Publications (27)

Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction.

Orphanet journal of rare diseases

Avec: Young-In Chi , Timothy J Stodola , Thiago M De Assuncao , Elise N Leverence , Swarnendu Tripathi , Nikita R Dsouza , Angela J Mathison , Donald G Basel , Brian F Volkman , Brian C Smith , Gwen Lomberk , Michael T Zimmermann , Raul Urrutia

NADPH oxidase 4 contributes to TRPV4-mediated endothelium-dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels.

Basic research in cardiology

Avec: Yangjing Xie , Yoshinori Nishijima , Natalya S Zinkevich , Ankush Korishettar , Juan Fang , Angela J Mathison , Michael T Zimmermann , David A Wilcox , David D Gutterman , Yuxian Shen , David X Zhang

A Multi-Layered Computational Structural Genomics Approach Enhances Domain-Specific Interpretation of Kleefstra Syndrome Variants in EHMT1.

bioRxiv : the preprint server for biology

Avec: Young-In Chi , Salomão D Jorge , Davin R Jensen , Brian C Smith , Brian F Volkman , Angela J Mathison , Gwen Lomberk , Michael T Zimmermann , Raul Urrutia

Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape.

Computational and structural biotechnology journal

Avec: Brian D Ratnasinghe , Neshatul Haque , Jessica B Wagenknecht , Davin R Jensen , Guadalupe K Valdivia Esparza , Elise N Leverence , Thiago Milech De Assuncao , Angela J Mathison , Gwen Lomberk , Brian C Smith , Brian F Volkman , Raul Urrutia , Michael T Zimmermann

Kras

Genome biology

Avec: Angela J Mathison , Romica Kerketta , Thiago Milech de Assuncao , Elise Leverence , Atefeh Zeighami , Guillermo Urrutia , Timothy J Stodola , Marina Pasca di Magliano , Juan L Iovanna , Michael T Zimmermann , Gwen Lomberk , Raul Urrutia

Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons.

Genes

Avec: Reilly L Allison , Jacob W Adelman , Jenica Abrudan , Raul A Urrutia , Michael T Zimmermann , Angela J Mathison , Allison D Ebert

Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers.

Computational and structural biotechnology journal

Avec: Young-In Chi , Timothy J Stodola , Thiago M De Assuncao , Elise N Leverence , Brian C Smith , Brian F Volkman , Angela J Mathison , Gwen Lomberk , Michael T Zimmermann , Raul Urrutia

EHMT2 Inactivation in Pancreatic Epithelial Cells Shapes the Transcriptional Landscape and Inflammation Response of the Whole Pancreas.

bioRxiv : the preprint server for biology

Avec: Gareth Pollin , Angela J Mathison , Thiago M de Assuncao , Anju Thomas , Lida Zeighami , Ann Salmonson , Hongfei Liu , Guillermo Urrutia , Pallavi Vankayala , Stephen J Pandol , Michael T Zimmermann , Juan Iovanna , Victor X Jin , Raul Urrutia , Gwen Lomberk

SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Chenxia He , Jeanne M Danes , Peter C Hart , Yueming Zhu , Yunping Huang , Andre Luelsdorf de Abreu , Joseph O'Brien , Angela J Mathison , Binwu Tang , Jonna M Frasor , Lalage M Wakefield , Douglas Ganini , Erich Stauder , Jacek Zielonka , Benjamin N Gantner , Raul A Urrutia , David Gius , Marcelo G Bonini

Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.

Cellular and molecular gastroenterology and hepatology

Avec: Rosa Martin-Mateos , Thiago M De Assuncao , Juan Pablo Arab , Nidhi Jalan-Sakrikar , Usman Yaqoob , Thomas Greuter , Vikas K Verma , Angela J Mathison , Sheng Cao , Gwen Lomberk , Philippe Mathurin , Raul Urrutia , Robert C Huebert , Vijay H Shah

Aurora kinase B-phosphorylated HP1α functions in chromosomal instability.

Cell cycle (Georgetown, Tex.)

Avec: Monique M Williams , Angela J Mathison , Trent Christensen , Patricia T Greipp , Darlene L Knutson , Eric W Klee , Michael T Zimmermann , Juan Iovanna , Gwen A Lomberk , Raul A Urrutia

Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level.

Frontiers in oncology

Avec: Michael T Zimmermann , Angela J Mathison , Tim Stodola , Douglas B Evans , Jenica L Abrudan , Wendy Demos , Michael Tschannen , Mohammed Aldakkak , Jennifer Geurts , Gwen Lomberk , Susan Tsai , Raul Urrutia

Inactivation of the Euchromatic Histone-Lysine

Frontiers in cell and developmental biology

Avec: Guillermo Urrutia , Thiago Milech de Assuncao , Angela J Mathison , Ann Salmonson , Romica Kerketta , Atefeh Zeighami , Timothy J Stodola , Volkan Adsay , Burcin Pehlivanoglu , Michael B Dwinell , Michael T Zimmermann , Juan L Iovanna , Raul Urrutia , Gwen Lomberk

The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis.

Nature communications

Avec: Lu Han , Yongxia Wu , Kun Fang , Sean Sweeney , Ulyss K Roesner , Melodie Parrish , Khushbu Patel , Tom Walter , Julia Piermattei , Anthony Trimboli , Julia Lefler , Cynthia D Timmers , Xue-Zhong Yu , Victor X Jin , Michael T Zimmermann , Angela J Mathison , Raul Urrutia , Michael C Ostrowski , Gustavo Leone

Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape.

bioRxiv : the preprint server for biology

Avec: Brian D Ratnasinghe , Neshatul Haque , Jessica B Wagenknecht , Davin R Jensen , Guadalupe V Esparza , Elise N Leverence , Thiago Milech De Assuncao , Angela J Mathison , Gwen Lomberk , Brian C Smith , Brian F Volkman , Raul Urrutia , Michael T Zimmermann

Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis.

Proteins

Avec: Timothy J Stodola , Young-In Chi , Thiago M De Assuncao , Elise N Leverence , Swarnendu Tripathi , Nikita R Dsouza , Angela J Mathison , Brian F Volkman , Brian C Smith , Gwen Lomberk , Michael T Zimmermann , Raul Urrutia

Pepsinogen/Proton Pump Co-Expression in Barrett's Esophageal Cells Induces Cancer-Associated Changes.

The Laryngoscope

Avec: Kaleigh A Stabenau , Tina L Samuels , Tina K Lam , Angela J Mathison , Clive Wells , Kenneth W Altman , Michele A Battle , Nikki Johnston

RhoBTB1 reverses established arterial stiffness in angiotensin II-induced hypertension by promoting actin depolymerization.

JCI insight

Avec: Shi Fang , Jing Wu , John J Reho , Ko-Ting Lu , Daniel T Brozoski , Gaurav Kumar , Alec M Werthman , Sebastiao Donato Silva , Patricia C Muskus Veitia , Kelsey K Wackman , Angela J Mathison , Bi Qing Teng , Chien-Wei Lin , Frederick W Quelle , Curt D Sigmund

Type I interferon signaling promotes radioresistance in head and neck cancer.

Translational cancer research

Avec: Joseph Zenga , Musaddiq J Awan , Anne Frei , Becky Massey , Jennifer Bruening , Monica Shukla , Guru Prasad Sharma , Aditya Shreenivas , Stuart J Wong , Michael T Zimmermann , Angela J Mathison , Heather A Himburg

Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function.

Function (Oxford, England)

Avec: Jennifer S Stancill , Polly A Hansen , Angela J Mathison , Edward E Schmidt , John A Corbett

Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation.

Annals of surgery open : perspectives of surgical history, education, and clinical approaches

Avec: Joohyun Kim , Michael T Zimmermann , Angela J Mathison , Gwen Lomberk , Raul Urrutia , Johnny C Hong

Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics.

Computational and structural biotechnology journal

Avec: Swarnendu Tripathi , Nikita R Dsouza , Angela J Mathison , Elise Leverence , Raul Urrutia , Michael T Zimmermann

Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Jeanne M Danes , Andre L P de Abreu , Romica Kerketta , Yunping Huang , Flavio R Palma , Benjamin N Gantner , Angela J Mathison , Raul A Urrutia , Marcelo G Bonini

BMI1 maintains the Treg epigenomic landscape to prevent inflammatory bowel disease.

The Journal of clinical investigation

Avec: Michelle M Gonzalez , Adebowale O Bamidele , Phyllis A Svingen , Mary R Sagstetter , Thomas C Smyrk , Joseph M Gaballa , Feda H Hamdan , Robyn Laura Kosinsky , Hunter R Gibbons , Zhifu Sun , Zhenqing Ye , Asha Nair , Guilherme P Ramos , Manuel B Braga Neto , Alexander Q Wixom , Angela J Mathison , Steven A Johnsen , Raul Urrutia , William A Faubion

A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1.

Computational and structural biotechnology journal

Avec: Young-In Chi , Salomão D Jorge , Davin R Jensen , Brian C Smith , Brian F Volkman , Angela J Mathison , Gwen Lomberk , Michael T Zimmermann , Raul Urrutia

Changes in Daily Apparent Diffusion Coefficient on Fully Quantitative Magnetic Resonance Imaging Correlate With Established Genomic Pathways of Radiation Sensitivity and Reveal Novel Biologic Associations.

International journal of radiation oncology, biology, physics

Avec: William A Hall , Angela J Mathison , Elias DeVoe , Michael Tschannen , Jaime Wendt-Andrae , Michael Straza , Musaddiq Awan , Lindsay L Puckett , Colleen A F Lawton , Christopher Schultz , Raul Urrutia , Sarah Kerns , Javier F Torres-Roca , X Allen Li , Beth Erickson , Marja T Nevalainen , Michael T Zimmermann , Eric Paulson

Global Transcriptomic Analysis of Topical Sodium Alginate Protection against Peptic Damage in an In Vitro Model of Treatment-Resistant Gastroesophageal Reflux Disease.

International journal of molecular sciences

Avec: Pelin Ergun , Tina L Samuels , Angela J Mathison , Kate Plehhova , Cathal Coyle , Lizzie Horvath , Nikki Johnston

Réseau de co-auteurs

Michael T Zimmermann 19 collaborations

Raul Urrutia 17 collaborations

Gwen Lomberk 13 collaborations

Brian F Volkman 7 collaborations

Brian C Smith 7 collaborations

Young-In Chi 5 collaborations

Timothy J Stodola 5 collaborations

Elise N Leverence 5 collaborations

Thiago M De Assuncao 4 collaborations

Davin R Jensen 4 collaborations

Raul A Urrutia 4 collaborations

Swarnendu Tripathi 3 collaborations

Nikita R Dsouza 3 collaborations

Romica Kerketta 3 collaborations

Guillermo Urrutia 3 collaborations

Salomão D Jorge 2 collaborations

Brian D Ratnasinghe 2 collaborations

Neshatul Haque 2 collaborations

Jessica B Wagenknecht 2 collaborations

Thiago Milech De Assuncao 2 collaborations

Thiago Milech de Assuncao 2 collaborations

Elise Leverence 2 collaborations

Atefeh Zeighami 2 collaborations

Juan L Iovanna 2 collaborations

Ann Salmonson 2 collaborations

Juan Iovanna 2 collaborations

Victor X Jin 2 collaborations

Jeanne M Danes 2 collaborations

Yunping Huang 2 collaborations

Benjamin N Gantner 2 collaborations

Marcelo G Bonini 2 collaborations

Michael Tschannen 2 collaborations

Tina L Samuels 2 collaborations

Nikki Johnston 2 collaborations

Donald G Basel 1 collaboration

Yangjing Xie 1 collaboration

Yoshinori Nishijima 1 collaboration

Natalya S Zinkevich 1 collaboration

Ankush Korishettar 1 collaboration

Juan Fang 1 collaboration

David A Wilcox 1 collaboration

David D Gutterman 1 collaboration

Yuxian Shen 1 collaboration

David X Zhang 1 collaboration

Guadalupe K Valdivia Esparza 1 collaboration

Marina Pasca di Magliano 1 collaboration

Reilly L Allison 1 collaboration

Jacob W Adelman 1 collaboration

Jenica Abrudan 1 collaboration

Allison D Ebert 1 collaboration

Gareth Pollin 1 collaboration

Thiago M de Assuncao 1 collaboration

Anju Thomas 1 collaboration

Lida Zeighami 1 collaboration

Hongfei Liu 1 collaboration

Pallavi Vankayala 1 collaboration

Stephen J Pandol 1 collaboration

Chenxia He 1 collaboration

Peter C Hart 1 collaboration

Yueming Zhu 1 collaboration

Andre Luelsdorf de Abreu 1 collaboration

Joseph O'Brien 1 collaboration

Binwu Tang 1 collaboration

Jonna M Frasor 1 collaboration

Lalage M Wakefield 1 collaboration

Douglas Ganini 1 collaboration

Erich Stauder 1 collaboration

Jacek Zielonka 1 collaboration

David Gius 1 collaboration

Rosa Martin-Mateos 1 collaboration

Juan Pablo Arab 1 collaboration

Nidhi Jalan-Sakrikar 1 collaboration

Usman Yaqoob 1 collaboration

Thomas Greuter 1 collaboration

Vikas K Verma 1 collaboration

Sheng Cao 1 collaboration

Philippe Mathurin 1 collaboration

Robert C Huebert 1 collaboration

Vijay H Shah 1 collaboration

Monique M Williams 1 collaboration

Trent Christensen 1 collaboration

Patricia T Greipp 1 collaboration

Darlene L Knutson 1 collaboration

Eric W Klee 1 collaboration

Gwen A Lomberk 1 collaboration

Tim Stodola 1 collaboration

Douglas B Evans 1 collaboration

Jenica L Abrudan 1 collaboration

Wendy Demos 1 collaboration

Mohammed Aldakkak 1 collaboration

Jennifer Geurts 1 collaboration

Susan Tsai 1 collaboration

Volkan Adsay 1 collaboration

Burcin Pehlivanoglu 1 collaboration

Michael B Dwinell 1 collaboration

Lu Han 1 collaboration

Yongxia Wu 1 collaboration

Kun Fang 1 collaboration

Sean Sweeney 1 collaboration

Ulyss K Roesner 1 collaboration

Melodie Parrish 1 collaboration

Khushbu Patel 1 collaboration

Tom Walter 1 collaboration

Julia Piermattei 1 collaboration

Anthony Trimboli 1 collaboration

Julia Lefler 1 collaboration

Cynthia D Timmers 1 collaboration

Xue-Zhong Yu 1 collaboration

Michael C Ostrowski 1 collaboration

Gustavo Leone 1 collaboration

Guadalupe V Esparza 1 collaboration

Kaleigh A Stabenau 1 collaboration

Tina K Lam 1 collaboration

Clive Wells 1 collaboration

Kenneth W Altman 1 collaboration

Michele A Battle 1 collaboration

Shi Fang 1 collaboration

Jing Wu 1 collaboration

John J Reho 1 collaboration

Ko-Ting Lu 1 collaboration

Daniel T Brozoski 1 collaboration

Gaurav Kumar 1 collaboration

Alec M Werthman 1 collaboration

Sebastiao Donato Silva 1 collaboration

Patricia C Muskus Veitia 1 collaboration

Kelsey K Wackman 1 collaboration

Bi Qing Teng 1 collaboration

Chien-Wei Lin 1 collaboration

Frederick W Quelle 1 collaboration

Curt D Sigmund 1 collaboration

Joseph Zenga 1 collaboration

Musaddiq J Awan 1 collaboration

Anne Frei 1 collaboration

Becky Massey 1 collaboration

Jennifer Bruening 1 collaboration

Monica Shukla 1 collaboration

Guru Prasad Sharma 1 collaboration

Aditya Shreenivas 1 collaboration

Stuart J Wong 1 collaboration

Heather A Himburg 1 collaboration

Jennifer S Stancill 1 collaboration

Polly A Hansen 1 collaboration

Edward E Schmidt 1 collaboration

John A Corbett 1 collaboration

Joohyun Kim 1 collaboration

Johnny C Hong 1 collaboration

Andre L P de Abreu 1 collaboration

Flavio R Palma 1 collaboration

Michelle M Gonzalez 1 collaboration

Adebowale O Bamidele 1 collaboration

Phyllis A Svingen 1 collaboration

Mary R Sagstetter 1 collaboration

Thomas C Smyrk 1 collaboration

Joseph M Gaballa 1 collaboration

Feda H Hamdan 1 collaboration

Robyn Laura Kosinsky 1 collaboration

Hunter R Gibbons 1 collaboration

Zhifu Sun 1 collaboration

Zhenqing Ye 1 collaboration

Asha Nair 1 collaboration

Guilherme P Ramos 1 collaboration

Manuel B Braga Neto 1 collaboration

Alexander Q Wixom 1 collaboration

Steven A Johnsen 1 collaboration

William A Faubion 1 collaboration

William A Hall 1 collaboration

Elias DeVoe 1 collaboration

Jaime Wendt-Andrae 1 collaboration

Michael Straza 1 collaboration

Musaddiq Awan 1 collaboration

Lindsay L Puckett 1 collaboration

Colleen A F Lawton 1 collaboration

Christopher Schultz 1 collaboration

Sarah Kerns 1 collaboration

Javier F Torres-Roca 1 collaboration

X Allen Li 1 collaboration

Beth Erickson 1 collaboration

Marja T Nevalainen 1 collaboration

Eric Paulson 1 collaboration

Pelin Ergun 1 collaboration

Kate Plehhova 1 collaboration

Cathal Coyle 1 collaboration

Lizzie Horvath 1 collaboration