Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function.
diabetes
insulin secretion
radicals
thioredoxin reductase
β-cells
Journal
Function (Oxford, England)
ISSN: 2633-8823
Titre abrégé: Function (Oxf)
Pays: England
ID NLM: 101770668
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
04
2022
revised:
17
06
2022
accepted:
27
06
2022
entrez:
25
7
2022
pubmed:
26
7
2022
medline:
26
7
2022
Statut:
epublish
Résumé
Reactive oxygen species (ROS) have been implicated as mediators of pancreatic β-cell damage. While β-cells are thought to be vulnerable to oxidative damage, we have shown, using inhibitors and acute depletion, that thioredoxin reductase, thioredoxin, and peroxiredoxins are the primary mediators of antioxidant defense in β-cells. However, the role of this antioxidant cycle in maintaining redox homeostasis and β-cell survival
Identifiants
pubmed: 35873655
doi: 10.1093/function/zqac034
pii: zqac034
pmc: PMC9301323
doi:
Substances chimiques
Antioxidants
0
Reactive Oxygen Species
0
NF-E2-Related Factor 2
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Pagination
zqac034Subventions
Organisme : NIAID NIH HHS
ID : R01 AI044458
Pays : United States
Organisme : NIH HHS
ID : R21 OD026444
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK052194
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL134643
Pays : United States
Organisme : NIDDK NIH HHS
ID : K99 DK129709
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK123738
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK123738
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA215784
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG055022
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG040020
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of American Physiological Society.
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