New candidate blood biomarkers potentially associated with white matter hyperintensities progression.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 07 2021
12 07 2021
Historique:
received:
10
03
2021
accepted:
18
06
2021
entrez:
13
7
2021
pubmed:
14
7
2021
medline:
6
11
2021
Statut:
epublish
Résumé
We aimed to discover blood biomarkers associated with longitudinal changes in white matter hyperintensities (WMH). This study was divided into a discovery phase and a replication phase. Subjects in both studies were patients with hypertension, aged 50-70, who underwent two magnetic resonance imaging (MRI) sessions and blood extractions over a 4-year follow-up period. In the discovery phase, we screened 1305 proteins in 12 subjects with WMH progression and in 12 matched control subjects. We found that 41 proteins were differentially expressed: 13 were upregulated and 28 were downregulated. We subsequently selected three biomarkers for replication in baseline and follow-up samples in 80 subjects with WMH progression and in 80 control subjects. The selected protein candidates for the replication were MMP9 (matrix metalloproteinase-9), which was higher in cases, MET (hepatocyte growth factor receptor) and ASAH2 (neutral ceramidase), which were both lower in cases of WMH progression. Baseline biomarker concentrations did not predict WMH progression. In contrast, patients with WMH progression presented a steeper decline in MET over time. Furthermore, cases showed higher MMP9 and lower ASAH2 levels than controls at the follow-up. These results indicate that MMP9, MET, and ASAH2 are potentially associated with the progression of WMH, and could therefore be interesting candidates to validate in future studies.
Identifiants
pubmed: 34253757
doi: 10.1038/s41598-021-93498-w
pii: 10.1038/s41598-021-93498-w
pmc: PMC8275657
doi:
Substances chimiques
Biomarkers
0
Proto-Oncogene Proteins c-met
EC 2.7.10.1
Matrix Metalloproteinase 9
EC 3.4.24.35
ASAH2 protein, human
EC 3.5.1.23
Neutral Ceramidase
EC 3.5.1.23
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14324Informations de copyright
© 2021. The Author(s).
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