Circulating Survivin Protein Levels in Lung Cancer Patients Treated With Platinum-Based Chemotherapy.
Adenocarcinoma of Lung
/ blood
Aged
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Biomarkers, Tumor
/ blood
Carcinoma, Squamous Cell
/ blood
Case-Control Studies
Female
Follow-Up Studies
Humans
Lung Neoplasms
/ blood
Male
Middle Aged
Pemetrexed
/ administration & dosage
Platinum
/ administration & dosage
Prognosis
Small Cell Lung Carcinoma
/ blood
Survival Rate
Survivin
/ blood
ELISA
biomarker
disease progression
lung cancer
survivin
Journal
Pathology oncology research : POR
ISSN: 1532-2807
Titre abrégé: Pathol Oncol Res
Pays: Switzerland
ID NLM: 9706087
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
11
2020
accepted:
01
04
2021
entrez:
14
7
2021
pubmed:
15
7
2021
medline:
4
1
2022
Statut:
epublish
Résumé
The survivin protein contributes to the development and progression of tumors. Protein expression and mRNA levels correlate with clinicopathological parameters and survival of cancer patients. Our purpose was to evaluate whether circulating survivin levels have any diagnostic or predictive value in lung cancer. 118 patients with advanced stage lung cancer participated in our study. 53 suffered from adenocarcinoma (ADC), 33 from squamous cell carcinoma (SqCC), and 32 from small cell lung cancer (SCLC). We also enrolled 21 control subjects. Blood samples were collected before and after two cycles of chemotherapy. We measured survivin concentrations with ELISA. Non-parametric tests were used for analysis. We did not find significant difference in survivin levels between patients and control subjects (17.19/0-829.74/vs. 49.13/0-165.92/pg/ml;
Identifiants
pubmed: 34257598
doi: 10.3389/pore.2021.631969
pii: 631969
pmc: PMC8262151
doi:
Substances chimiques
BIRC5 protein, human
0
Biomarkers, Tumor
0
Survivin
0
Pemetrexed
04Q9AIZ7NO
Platinum
49DFR088MY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
631969Informations de copyright
Copyright © 2021 Puskas, Bikov, Horvath, Lazar, Kunos, Nagy, Pinter and Galffy.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cancer Res. 1998 Dec 1;58(23):5315-20
pubmed: 9850056
Cancer. 2009 Jul 1;115(13):2930-8
pubmed: 19441110
Curr Biol. 2000 Nov 2;10(21):1319-28
pubmed: 11084331
Apoptosis. 2011 Jan;16(1):1-12
pubmed: 20717727
Lung Cancer. 2013 Aug;81(2):273-9
pubmed: 23756092
World J Surg Oncol. 2015 May 28;13:189
pubmed: 26016480
J Thorac Oncol. 2015 Nov;10(11):1515-22
pubmed: 26536193
Lung Cancer. 2008 Feb;59(2):240-5
pubmed: 17875341
Indian J Med Res. 2015 Apr;141(4):389-97
pubmed: 26112839
Med Oncol. 2014 Jan;31(1):775
pubmed: 24338338
Oncol Lett. 2015 Sep;10(3):1456-1462
pubmed: 26622690
Virchows Arch. 2013 Sep;463(3):427-36
pubmed: 23907568
J Cancer Res Clin Oncol. 2011 Mar;137(3):505-12
pubmed: 20490863
Clin Cancer Res. 2008 Aug 15;14(16):5000-5
pubmed: 18698017
Med Oncol. 2006;23(3):335-9
pubmed: 17018890
Cancer Res. 2010 Oct 15;70(20):7927-37
pubmed: 20807805
Folia Histochem Cytobiol. 2009;47(4):703-9
pubmed: 20430742
Lung Cancer. 2009 Feb;63(2):284-90
pubmed: 18606477
Anticancer Res. 2013 Aug;33(8):3475-80
pubmed: 23898122
Br J Cancer. 2009 Apr 7;100(7):1073-86
pubmed: 19293795
Semin Cell Dev Biol. 2015 Mar;39:91-6
pubmed: 25591986
Int J Oncol. 2009 Dec;35(6):1449-62
pubmed: 19885569
Chin Med J (Engl). 2008 Nov 20;121(22):2234-40
pubmed: 19080323
Drug Discov Today. 2011 Jun;16(11-12):485-94
pubmed: 21511051
Tumour Biol. 2014 May;35(5):4499-507
pubmed: 24390669
Melanoma Res. 2004 Dec;14(6):543-6
pubmed: 15577328
Mol Cancer. 2014 Sep 09;13:209
pubmed: 25204429
Adv Exp Med Biol. 2015;873:101-7
pubmed: 26022894
J Egypt Natl Canc Inst. 2012 Mar;24(1):41-5
pubmed: 23587231
Anticancer Res. 2015 May;35(5):2935-9
pubmed: 25964579
BMC Cancer. 2016 Apr 18;16:276
pubmed: 27090386
Transl Lung Cancer Res. 2019 Dec;8(6):1107-1118
pubmed: 32010588
Nat Med. 1997 Aug;3(8):917-21
pubmed: 9256286