Mutations of

Adult Animals Cells, Cultured China / epidemiology Cohort Studies DNA Mutational Analysis Female Genetic Association Studies Humans Male Metabolic Diseases / epidemiology Mice Mice, Inbred C57BL Mice, Transgenic Middle Aged Mutation Neuregulins / genetics Non-alcoholic Fatty Liver Disease / complications Obesity / epidemiology Young Adult

Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
10 2021
Historique:
received: 28 01 2021
accepted: 08 07 2021
pubmed: 16 7 2021
medline: 22 12 2021
entrez: 15 7 2021
Statut: ppublish

Résumé

Neuregulin 4 (Nrg4), an adipose tissue-enriched endocrine factor, participates in adipocyte-to-hepatocyte communication, eliciting beneficial metabolic effects in nonalcoholic fatty liver disease (NAFLD). We evaluate the physiological roles of NRG4 in humans and unravel the role of

Identifiants

DOI: 10.2337/db21-0064 PMID: 34261740
pubmed: 34261740
pii: db21-0064
doi: 10.2337/db21-0064
doi:

Substances chimiques

Neuregulins 0
neuregulin-4 0

Banques de données

figshare
['10.2337/figshare.14938995']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2213-2224

Informations de copyright

© 2021 by the American Diabetes Association.

Auteurs

Yangyang Li (Y)

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Li Jin (L)

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Feng Jiang (F)

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Jing Yan (J)

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Yan Lu (Y)

The Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
ORCID: 0000-0003-3468-2241

Qing Yang (Q)

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Yi Zhang (Y)

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Hong Zhang (H)

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Hairong Yu (H)

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Yuemei Zhang (Y)

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Zhen He (Z)

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Rong Zhang (R)

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Jianjun Yang (J)

Department of General Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China alfredhc@sjtu.edu.cn ayang1230@126.com.

Cheng Hu (C)

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China alfredhc@sjtu.edu.cn ayang1230@126.com.
Institute for Metabolic Disease, Fengxian Central Hospital Affiliated to Southern Medical University, Shanghai, China.
ORCID: 0000-0003-4314-2386

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Mutations of
questionsmedicales.fr › Eucaryotes › Animaux › Mutations of
questionsmedicales.fr › Cellules › Cellules cultivées › Mutations of
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › Mutations of
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Mutations of
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Analyse de mutations d'ADN › Mutations of
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Études d'associations génétiques › Mutations of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mutations of
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Mutations of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mutations of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Mutations of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Mutations of
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Mutations of
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutations of
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Neurégulines › Mutations of
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › Mutations of
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Mutations of
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Mutations of