Evaluation of peripherin in biofluids of patients with motor neuron diseases.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
06
05
2021
received:
24
02
2021
accepted:
17
06
2021
pubmed:
16
7
2021
medline:
27
1
2022
entrez:
15
7
2021
Statut:
ppublish
Résumé
Peripherin (PRPH), a type III intermediate filament, assembles with neurofilaments in neurons of the peripheral nervous system, including lower motor neurons (LMN). To evaluate the role of PRPH in LMN degeneration, we assessed PRPH and neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum of 91 patients with motor neuron diseases (MND) and 69 controls. Overall, we found PRPH to be more concentrated in serum than in CSF. Serum PRPH resulted significantly increased in MND patients but it was unrelated to CSF-NfL or survival in the amyotrophic lateral sclerosis (ALS) subset. PRPH might represent a marker of LMN involvement.
Identifiants
pubmed: 34264016
doi: 10.1002/acn3.51419
pmc: PMC8351396
doi:
Substances chimiques
Biomarkers
0
Neurofilament Proteins
0
PRPH protein, human
0
Peripherins
0
neurofilament protein L
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1750-1754Informations de copyright
© 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
Références
Neurology. 2006 Jan 24;66(2):265-7
pubmed: 16434671
Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1(5):293-9
pubmed: 11464847
Curr Opin Neurobiol. 2020 Apr;61:105-115
pubmed: 32151970
J Neurochem. 2002 May;81(3):525-32
pubmed: 12065660
J Cell Biol. 1999 Nov 1;147(3):531-44
pubmed: 15132161
Mol Biol Cell. 2003 Dec;14(12):5069-81
pubmed: 14595112
Neuroscience. 2000;101(3):679-88
pubmed: 11113316
J Neurochem. 2006 Aug;98(3):926-38
pubmed: 16787413
Methods Enzymol. 2016;568:477-507
pubmed: 26795481
Brain. 2010 Aug;133(Pt 8):2313-30
pubmed: 20826431
J Neurol Neurosurg Psychiatry. 2016 Jan;87(1):12-20
pubmed: 26296871
Muscle Nerve. 2012 Feb;45(2):169-74
pubmed: 22246870
Neurology. 2015 Jun 2;84(22):2247-57
pubmed: 25934855
Mol Neurodegener. 2020 Oct 15;15(1):58
pubmed: 33059698
JAMA Neurol. 2017 May 1;74(5):525-532
pubmed: 28264096
J Neurol. 2020 Jan;267(1):36-44
pubmed: 31552549
Neurobiol Aging. 2011 Mar;32(3):552.e1-6
pubmed: 20363051
J Neurosci. 2012 Jun 20;32(25):8501-8
pubmed: 22723690
Neurology. 2019 Mar 12;92(11):e1205-e1211
pubmed: 30787165
J Biol Chem. 2004 Oct 29;279(44):45951-6
pubmed: 15322088
J Neuropathol Exp Neurol. 1992 Sep;51(5):531-7
pubmed: 1381416
Front Neurol. 2015 Aug 19;6:179
pubmed: 26347708