Perspective: Moving Toward Desirable Linoleic Acid Content in Infant Formula.

Humans Infant Infant Formula Infant Nutritional Physiological Phenomena Linoleic Acid Milk, Human Nutritional Requirements
LCPUFAs human milk composition infant development infant formula linoleic acid nutritional programming

Journal

Advances in nutrition (Bethesda, Md.)
ISSN: 2156-5376
Titre abrégé: Adv Nutr
Pays: United States
ID NLM: 101540874

Informations de publication

Date de publication:
01 12 2021
Historique:
received: 28 02 2021
revised: 19 05 2021
accepted: 24 05 2021
pubmed: 16 7 2021
medline: 2 2 2022
entrez: 15 7 2021
Statut: ppublish

Résumé

Infant formula should provide the appropriate nutrients and adequate energy to facilitate healthy infant growth and development. If conclusive data on quantitative nutrient requirements are not available, the composition of human milk (HM) can provide some initial guidance on the infant formula composition. This paper provides a narrative review of the current knowledge, unresolved questions, and future research needs in the area of HM fatty acid (FA) composition, with a particular focus on exploring appropriate intake levels of the essential FA linoleic acid (LA) in infant formula. The paper highlights a clear gap in clinical evidence as to the impact of LA levels in HM or formula on infant outcomes, such as growth, development, and long-term health. The available preclinical information suggests potential disadvantages of high LA intake in the early postnatal period. We recommend performing well-designed clinical intervention trials to create clarity on optimal levels of LA to achieve positive impacts on both short-term growth and development and long-term functional health outcomes.

Identifiants

DOI: 10.1093/advances/nmab076 PMID: 34265035 PMC: PMC8634410
pubmed: 34265035
pii: S2161-8313(22)00493-8
doi: 10.1093/advances/nmab076
pmc: PMC8634410
doi:

Substances chimiques

Linoleic Acid 9KJL21T0QJ

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

2085-2098

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

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Auteurs

Susan E Carlson (SE)

Department of Dietetics and Nutrition, Kansas University Medical Center, Kansas City, KS, USA.
ORCID: 0000-0003-3579-1685

Lidewij Schipper (L)

Danone Nutricia Research, Utrecht, The Netherlands.

J Thomas Brenna (JT)

Department of Pediatrics, University of Texas at Austin, Austin, TX, USA.
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.

Carlo Agostoni (C)

Pediatric Area, Fondazione IRCCS Ca'Granda- Ospedale Maggiore Policlinico, Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
ORCID: 0000-0002-5006-0832

Philip C Calder (PC)

Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

Stewart Forsyth (S)

University of Dundee, West Ferry, Dundee, United Kingdom.

Philippe Legrand (P)

Laboratoire de Biochimie-Nutrition Humaine, Agrocampus-French National Institute of Health and Medical Research, Rennes, France.

Marieke Abrahamse-Berkeveld (M)

Danone Nutricia Research, Utrecht, The Netherlands.

Bert J M van de Heijning (BJM)

Danone Nutricia Research, Utrecht, The Netherlands.

Eline M van der Beek (EM)

Danone Nutricia Research, Utrecht, The Netherlands.
Department of Pediatrics, University Medical Center, Groningen, The Netherlands.

Berthold V Koletzko (BV)

Ludwig-Maximilians-Universität Munich, Department of Paediatrics, Dr von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.

Beverly Muhlhausler (B)

Nutrition and Health Program, Health and Biosecurity, CSIRO, Adelaide, Australia.
School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, Australia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Perspective: Moving Toward Desirable Linoleic...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Perspective: Moving Toward Desirable Linoleic...
questionsmedicales.fr › Aliments et boissons › Aliments › Aliments spécifiques › Aliment du nourrisson au cours de la première année › Préparation pour nourrissons › Perspective: Moving Toward Desirable Linoleic...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Phénomènes physiologiques nutritionnels chez l'enfant › Phénomènes physiologiques nutritionnels chez le nourrisson › Perspective: Moving Toward Desirable Linoleic...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras omega-6 › Acides linoléiques › Acide linoléique › Perspective: Moving Toward Desirable Linoleic...
questionsmedicales.fr › Aliments et boissons › Aliments › Produits laitiers › Lait › Lait humain › Perspective: Moving Toward Desirable Linoleic...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Besoins nutritifs › Perspective: Moving Toward Desirable Linoleic...