Overexpression of helper T cell type 2-related molecules in the skin of patients with eosinophilic dermatosis of hematologic malignancy.
B-cell lymphoma
bullous pemphigoid
eosinophilic dermatosis
eotaxin-1
interleukin 31
interleukin 4
Journal
Journal of the American Academy of Dermatology
ISSN: 1097-6787
Titre abrégé: J Am Acad Dermatol
Pays: United States
ID NLM: 7907132
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
27
01
2021
revised:
16
06
2021
accepted:
04
07
2021
pubmed:
16
7
2021
medline:
21
9
2022
entrez:
15
7
2021
Statut:
ppublish
Résumé
Eosinophilic dermatosis of hematologic malignancy (EDHM) is a rare dermatosis associated with blood tumors. To characterize the expression of T-cell and B-cell markers and pruritogenic mediators in EDHM skin. Immunohistochemical and immunofluorescence analysis were performed in 12 skin samples of EDHM, 11 samples of bullous pemphigoid (BP), and 5 samples from healthy controls (HC). Serum levels of interleukin (IL) 4 were analyzed in 11 patients with EDHM, 11 BP patients, and 5 HC by enzyme-linked immunosorbent assay. T-cell markers, including clusters of differentiation (CD) 3, CD4, CD8, and CD5 were significantly overexpressed in EDHM and BP skin compared to HC. A predominance of CD4 Small sample size; retrospective design. Targeting Th2-related molecules, in particular IL-4, holds promise for EDHM management.
Sections du résumé
BACKGROUND
Eosinophilic dermatosis of hematologic malignancy (EDHM) is a rare dermatosis associated with blood tumors.
OBJECTIVE
To characterize the expression of T-cell and B-cell markers and pruritogenic mediators in EDHM skin.
METHODS
Immunohistochemical and immunofluorescence analysis were performed in 12 skin samples of EDHM, 11 samples of bullous pemphigoid (BP), and 5 samples from healthy controls (HC). Serum levels of interleukin (IL) 4 were analyzed in 11 patients with EDHM, 11 BP patients, and 5 HC by enzyme-linked immunosorbent assay.
RESULTS
T-cell markers, including clusters of differentiation (CD) 3, CD4, CD8, and CD5 were significantly overexpressed in EDHM and BP skin compared to HC. A predominance of CD4
LIMITATIONS
Small sample size; retrospective design.
CONCLUSIONS
Targeting Th2-related molecules, in particular IL-4, holds promise for EDHM management.
Identifiants
pubmed: 34265409
pii: S0190-9622(21)02090-9
doi: 10.1016/j.jaad.2021.07.007
pii:
doi:
Substances chimiques
Chemokine CCL11
0
Forkhead Transcription Factors
0
Interleukins
0
Interleukin-4
207137-56-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
761-770Informations de copyright
Copyright © 2021 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest None disclosed.