Validation of serum apolipoprotein A1 in rabies virus-infected mice as a biomarker for the preclinical diagnosis of rabies.
ApoA1
biomarker
in vivo imaging
proteomics
rabies
Journal
Microbiology and immunology
ISSN: 1348-0421
Titre abrégé: Microbiol Immunol
Pays: Australia
ID NLM: 7703966
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
revised:
01
07
2021
received:
08
05
2021
accepted:
05
07
2021
pubmed:
17
7
2021
medline:
21
10
2021
entrez:
16
7
2021
Statut:
ppublish
Résumé
Rabies is a type of acute fetal encephalitis caused by rabies virus (RABV). While it becomes incurable after symptom onset, it can be prevented by post-exposure prophylaxis (PEP) during the long incubation period. While preclinical diagnosis aids the appropriate PEP administration, it is mostly nonfeasible owing to the absence of viremia or a specific antibody response during the incubation period. Here, an attempt was made to identify a serum biomarker for the preclinical diagnosis of rabies. Using the serum from a mouse inoculated intramuscularly (i.m.) with 5 × 10
Identifiants
pubmed: 34270107
doi: 10.1111/1348-0421.12929
pmc: PMC9292310
doi:
Substances chimiques
Antibodies, Viral
0
Apolipoprotein A-I
0
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
438-448Subventions
Organisme : Science and Technology Research Partnership for Sustainable Development (SATREPS)
ID : 17823721
Organisme : Japan Agency for Medical Research and Development (AMED)/JICA
Informations de copyright
© 2021 The Authors. Microbiology and Immunology published by The Societies and John Wiley & Sons Australia, Ltd.
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