Enantiomers of 4-aminopentanoic acid act as false GABAergic neurotransmitters and impact mouse behavior.
Animals
Brain
/ metabolism
Brain Chemistry
Dose-Response Relationship, Drug
Exploratory Behavior
/ drug effects
Locomotion
/ drug effects
Male
Mice
Mice, Inbred C57BL
Neurotransmitter Agents
/ chemistry
Pentanoic Acids
/ chemistry
Receptors, GABA-A
/ chemistry
Stereoisomerism
Synaptosomes
/ metabolism
gamma-Aminobutyric Acid
/ chemistry
GABA
Synaptic metabolism
mouse behavior
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
07
07
2021
received:
19
04
2021
accepted:
11
07
2021
pubmed:
18
7
2021
medline:
18
11
2021
entrez:
17
7
2021
Statut:
ppublish
Résumé
Imbalance in the metabolic pathway linking excitatory and inhibitory neurotransmission has been implicated in multiple psychiatric and neurologic disorders. Recently, we described enantiomer-specific effects of 2-methylglutamate, which is not decarboxylated to the corresponding methyl analogue of gamma-aminobutyric acid (GABA): 4-aminopentanoic acid (4APA). Here, we tested the hypothesis that 4APA also has enantiomer-specific actions in brain. Mouse cerebral synaptosome uptake (nmol/mg protein over 30 min) of (R)-4APA or (S)-4APA was time and temperature dependent; however, the R enantiomer had greater uptake, reduction of endogenous GABA concentration, and release following membrane depolarization than did the S enantiomer. (S)-4APA exhibited some weak agonist (GABA
Substances chimiques
Neurotransmitter Agents
0
Pentanoic Acids
0
Receptors, GABA-A
0
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1074-1082Subventions
Organisme : Smart Foundation
Informations de copyright
© 2021 International Society for Neurochemistry.
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