Large Animal Models of Vascularized Composite Allotransplantation: A Review of Immune Strategies to Improve Allograft Outcomes.

Allografts / immunology Animals Biomarkers Cell- and Tissue-Based Therapy / methods Graft Rejection / immunology Graft Survival / immunology Immune Tolerance Immunosuppression Therapy / methods Immunosuppressive Agents / pharmacology Models, Animal Organ Transplantation Perfusion Transplantation, Homologous Vascularized Composite Allotransplantation / methods
cellular therapies ex vivo perfusion large animal model transplantation tolerance induction vascularized composite allograft

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2021
Historique:
received: 05 02 2021
accepted: 07 06 2021
entrez: 19 7 2021
pubmed: 20 7 2021
medline: 21 10 2021
Statut: epublish

Résumé

Over the past twenty years, significant technical strides have been made in the area of vascularized composite tissue allotransplantation (VCA). As in solid organ transplantation, the allogeneic immune response remains a significant barrier to long-term VCA survival and function. Strategies to overcome acute and chronic rejection, minimize immunosuppression and prolong VCA survival have important clinical implications. Historically, large animals have provided a valuable model for testing the clinical translatability of immune modulating approaches in transplantation, including tolerance induction, co-stimulation blockade, cellular therapies, and

Identifiants

DOI: 10.3389/fimmu.2021.664577 PMID: 34276656 PMC: PMC8278218
pubmed: 34276656
doi: 10.3389/fimmu.2021.664577
pmc: PMC8278218
doi:

Substances chimiques

Biomarkers 0
Immunosuppressive Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

664577

Informations de copyright

Copyright © 2021 Matar, Crepeau, Mundinger, Cetrulo and Torabi.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Transpl Int. 2016 Jun;29(6):655-62
pubmed: 26265179
N Engl J Med. 2012 Feb 23;366(8):715-22
pubmed: 22204672
Transplantation. 2004 Feb 27;77(4):514-21
pubmed: 15084927
Ann Surg. 2018 May;267(5):983-988
pubmed: 28509699
Diabetes Care. 2011 Sep;34(9):2026-32
pubmed: 21680720
Am J Transplant. 2016 Jul;16(7):2030-41
pubmed: 26914847
Ann Plast Surg. 2008 Feb;60(2):209-16
pubmed: 18216518
Transplantation. 2002 Jun 15;73(11):1757-64
pubmed: 12084998
Curr Opin Organ Transplant. 2013 Dec;18(6):652-8
pubmed: 24220047
Plast Reconstr Surg. 2011 Dec;128(6):1193-1204
pubmed: 21841529
Ann Plast Surg. 2014 May;72(5):594-8
pubmed: 24317241
Am J Transplant. 2014 Feb;14(2):343-55
pubmed: 24405666
Clin Dev Immunol. 2013;2013:495212
pubmed: 23476677
Curr Opin Organ Transplant. 2014 Aug;19(4):348-56
pubmed: 24926700
Transplantation. 2010 Dec 27;90(12):1312-20
pubmed: 21042238
Laryngoscope. 2017 Aug;127(8):1861-1868
pubmed: 28224630
Curr Opin Organ Transplant. 2018 Oct;23(5):582-591
pubmed: 30102615
Am J Transplant. 2015 Aug;15(8):2231-9
pubmed: 25904524
Sci Transl Med. 2014 Aug 13;6(249):249ra110
pubmed: 25122638
JCI Insight. 2020 Apr 9;5(7):
pubmed: 32271163
Cold Spring Harb Perspect Med. 2014 Mar 01;4(3):
pubmed: 24478387
Am J Transplant. 2012 Feb;12(2):330-40
pubmed: 22053723
J Hand Surg Am. 2016 Jan;41(1):3-12
pubmed: 26710728
J Surg Res. 2018 Dec;232:137-145
pubmed: 30463709
Am J Transplant. 2017 Jul;17(7):1729-1741
pubmed: 28035752
N Engl J Med. 2019 Jun 27;380(26):2579-2581
pubmed: 31141626
Transplantation. 2013 Aug 15;96(3):234-8
pubmed: 23759879
PLoS One. 2012;7(4):e35459
pubmed: 22558153
Comp Med. 2016;66(4):308-23
pubmed: 27538862
Plast Reconstr Surg. 2020 Apr;145(4):757e-768e
pubmed: 32221215
Transplant Proc. 2011 Nov;43(9):3541-4
pubmed: 22099837
J Burn Care Res. 2018 Apr 20;39(3):363-373
pubmed: 28639977
Front Immunol. 2014 May 19;5:148
pubmed: 24904568
Transplantation. 2015 Oct;99(10):2095-101
pubmed: 25929606
Am J Transplant. 2017 Jun;17(6):1476-1489
pubmed: 28009481
Cell Mol Immunol. 2021 Feb;18(2):363-373
pubmed: 31754236
Transplantation. 2017 Feb;101(2):274-283
pubmed: 27846155
Nat Med. 1999 Nov;5(11):1298-302
pubmed: 10545997
Front Immunol. 2019 Jun 04;10:1287
pubmed: 31231393
Diabetes. 2010 Oct;59(10):2558-68
pubmed: 20622174
Transplantation. 2016 Oct;100(10):2053-61
pubmed: 27163543
Transplantation. 2016 Dec;100(12):e120-e127
pubmed: 27861292
N Engl J Med. 2016 Jan 28;374(4):333-43
pubmed: 26816011
Semin Immunol. 2012 Apr;24(2):115-21
pubmed: 22051115
Plast Reconstr Surg. 2011 Feb;127(2):569-579
pubmed: 21285761
Ann Rheum Dis. 2017 Jan;76(1):227-234
pubmed: 27117700
Curr Opin Organ Transplant. 2014 Jun;19(3):309-14
pubmed: 24811439
Transplantation. 2014 Jul 27;98(2):131-8
pubmed: 24918616
Transplantation. 2011 Dec 27;92(12):1301-8
pubmed: 22082819
Am J Transplant. 2005 Mar;5(3):443-53
pubmed: 15707398
Transplantation. 2018 Oct;102(10):1684-1694
pubmed: 29794937
Transplantation. 2009 Jun 27;87(12):1769-77
pubmed: 19543052
Am J Transplant. 2013 Aug;13(8):1989-2005
pubmed: 23758811
Curr Opin Organ Transplant. 2018 Apr;23(2):151-161
pubmed: 29324518
Transplantation. 2009 Dec 15;88(11):1242-50
pubmed: 19996923
Am J Transplant. 2004 Sep;4(9):1391-8
pubmed: 15307826
Ann Plast Surg. 2019 Apr;82(4):452-458
pubmed: 30628928
Am J Transplant. 2015 Aug;15(8):2240-9
pubmed: 26139552
Ann Surg. 2013 Feb;257(2):345-51
pubmed: 23001085
Transpl Int. 2020 Oct;33(10):1294-1301
pubmed: 32277724
Plast Reconstr Surg. 2009 Feb;123(2):493-501
pubmed: 19182606
Surgery. 2008 Oct;144(4):638-43; discussion 643-4
pubmed: 18847649
Am J Transplant. 2015 Jul;15(7):2011-2
pubmed: 25908397
Transplantation. 2013 May 27;95(10):1204-10
pubmed: 23694932
Transplantation. 2005 Nov 27;80(10):1447-54
pubmed: 16340790
Front Immunol. 2012 Sep 26;3:297
pubmed: 23056000
Artif Organs. 2020 Aug;44(8):846-855
pubmed: 32133657
Nat Biotechnol. 2017 Jun 7;35(6):530-542
pubmed: 28591112
Front Immunol. 2019 Jun 04;10:1191
pubmed: 31214172
Transplantation. 1995 Jan 27;59(2):256-62
pubmed: 7839449
PLoS One. 2019 Jan 24;14(1):e0210914
pubmed: 30677062
Am J Transplant. 2011 Jul;11(7):1407-16
pubmed: 21668624
N Engl J Med. 2008 Jan 24;358(4):353-61
pubmed: 18216355

Auteurs

Abraham J Matar (AJ)

Department of Surgery, Emory University School of Medicine, Atlanta, GA, United States.

Rebecca L Crepeau (RL)

Department of Surgery, Emory University School of Medicine, Atlanta, GA, United States.

Gerhard S Mundinger (GS)

Department of Surgery, Division of Plastic and Reconstructive Surgery, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, United States.

Curtis L Cetrulo (CL)

Department of Surgery, Division of Plastic Surgery, Massachusetts General Hospital, Boston, MA, United States.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.
Shriner's Hospital for Children, Department of Plastic and Reconstructive Surgery, Boston, MA, United States.

Radbeh Torabi (R)

Department of Surgery, Division of Plastic and Reconstructive Surgery, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, United States.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

Within-subject variation of C-reactive protein and high-sensitivity C-reactive protein: A systematic review and meta-analysis.

Alex Gough, Alice Sitch, Erica Ferris et al.
1.00
C-Reactive Protein Humans Biomarkers Inflammation

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Classifications MeSH

questionsmedicales.fr › Régions du corps › Transplants › Allogreffes › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Eucaryotes › Animaux › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Thérapeutique › Biothérapie › Thérapie cellulaire et tissulaire › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Rejet du greffon › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Survie du greffon › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunosuppresseurs › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation d'organe › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Techniques d'investigation › Perfusion › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation homologue › Large Animal Models of Vascularized Composite...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation homologue › Allotransplantation composite vascularisée › Large Animal Models of Vascularized Composite...