Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.
Acute mental stress
Atherosclerosis
Leucocyte recruitment
Neuroimmune interaction
Sympathetic nervous system
Vascular inflammation
Journal
European heart journal
ISSN: 1522-9645
Titre abrégé: Eur Heart J
Pays: England
ID NLM: 8006263
Informations de publication
Date de publication:
14 10 2021
14 10 2021
Historique:
received:
05
06
2020
revised:
15
11
2020
accepted:
03
06
2021
pubmed:
20
7
2021
medline:
30
1
2022
entrez:
19
7
2021
Statut:
ppublish
Résumé
Mental stress substantially contributes to the initiation and progression of human disease, including cardiovascular conditions. We aim to investigate the underlying mechanisms of these contributions since they remain largely unclear. Here, we show in humans and mice that leucocytes deplete rapidly from the blood after a single episode of acute mental stress. Using cell-tracking experiments in animal models of acute mental stress, we found that stress exposure leads to prompt uptake of inflammatory leucocytes from the blood to distinct tissues including heart, lung, skin, and, if present, atherosclerotic plaques. Mechanistically, we found that acute stress enhances leucocyte influx into mouse atherosclerotic plaques by modulating endothelial cells. Specifically, acute stress increases adhesion molecule expression and chemokine release through locally derived norepinephrine. Either chemical or surgical disruption of norepinephrine signalling diminished stress-induced leucocyte migration into mouse atherosclerotic plaques. Our data show that acute mental stress rapidly amplifies inflammatory leucocyte expansion inside mouse atherosclerotic lesions and promotes plaque vulnerability.
Identifiants
pubmed: 34279021
pii: 6323689
doi: 10.1093/eurheartj/ehab371
pmc: PMC8516477
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4077-4088Subventions
Organisme : European Research Council
ID : 635872
Pays : International
Organisme : British Heart Foundation
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.
Références
Nat Med. 2014 Jul;20(7):754-758
pubmed: 24952646
Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5808-13
pubmed: 15817686
Nature. 2019 Feb;566(7744):383-387
pubmed: 30760925
Circulation. 1999 Apr 27;99(16):2192-217
pubmed: 10217662
Eur Heart J. 2019 May 21;40(20):1590-1596
pubmed: 30860255
Nat Rev Cardiol. 2010 Feb;7(2):77-86
pubmed: 20065951
Nat Med. 2019 Nov;25(11):1761-1771
pubmed: 31700184
Nat Rev Immunol. 2007 Sep;7(9):678-89
pubmed: 17717539
Lancet. 2004 Sep 11-17;364(9438):937-52
pubmed: 15364185
Circ Res. 2020 Apr 24;126(9):1242-1259
pubmed: 32324501
Nat Med. 2018 Jun;24(6):711-720
pubmed: 29867229
Int J Physiol Pathophysiol Pharmacol. 2018 Mar 10;10(1):17-28
pubmed: 29593847
Circulation. 2016 Oct 11;134(15):1059-1067
pubmed: 27753614
JACC Cardiovasc Imaging. 2020 Feb;13(2 Pt 1):478-480
pubmed: 30448129
Brain Behav Immun. 2015 May;46:87-95
pubmed: 25557189
Immunity. 2013 Jan 24;38(1):79-91
pubmed: 23273845
Eur Heart J. 2014 Jun 1;35(21):1404-10
pubmed: 24591550
Neurosci Biobehav Rev. 1994 Summer;18(2):223-49
pubmed: 8058215
Lancet. 2017 Feb 25;389(10071):834-845
pubmed: 28088338
Nature. 2020 Jan;577(7792):676-681
pubmed: 31969699
N Engl J Med. 2013 May 23;368(21):2004-13
pubmed: 23697515
J Am Coll Cardiol. 2008 Apr 1;51(13):1237-46
pubmed: 18371552
Cardiovasc Res. 2015 Aug 1;107(3):321-30
pubmed: 25990461
J Exp Med. 2020 Apr 6;217(4):
pubmed: 32045472
Mol Ther. 2018 Apr 4;26(4):1040-1055
pubmed: 29503197
Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6920-4
pubmed: 10359814
J Physiol. 1976 Dec;263(2):157-69
pubmed: 1018230
Sci Transl Med. 2016 Jun 8;8(342):342ra80
pubmed: 27280687
Circ Res. 2020 Jul 3;127(2):269-283
pubmed: 32241223
N Engl J Med. 2008 Jan 31;358(5):475-83
pubmed: 18234752
Circulation. 2019 Sep 24;140(13):1100-1114
pubmed: 31401849
Nat Rev Immunol. 2005 Mar;5(3):243-51
pubmed: 15738954
Eur Heart J. 2017 Aug 1;38(29):2297-2299
pubmed: 28641401
N Engl J Med. 1996 Feb 15;334(7):413-9
pubmed: 8552142
Nat Med. 2014 Jul;20(7):707-8
pubmed: 24999940
Cell. 2020 Jul 23;182(2):372-387.e14
pubmed: 32610084
J Exp Med. 2017 Jul 3;214(7):1913-1923
pubmed: 28606987
Sci Transl Med. 2014 Sep 3;6(252):252ps9
pubmed: 25186174
Nat Rev Cardiol. 2018 Apr;15(4):215-229
pubmed: 29213140
Immunity. 2014 Jan 16;40(1):91-104
pubmed: 24439267
Lancet. 1991 Sep 14;338(8768):660-1
pubmed: 1679475
Immunity. 2012 Aug 24;37(2):290-301
pubmed: 22863835
Eur Heart J. 2021 May 14;42(19):1883-1895
pubmed: 33462618
Eur Heart J. 2013 Jan;34(4):300-6
pubmed: 23178642
Nat Rev Cardiol. 2012 Apr 03;9(6):360-70
pubmed: 22473079
Circ Res. 2014 Jan 3;114(1):214-26
pubmed: 24385514