The Association between Sex and Risk of Alzheimer's Disease in Adults with Down Syndrome.
APOE4
Alzheimer’s Disease
Down Syndrome
sex difference
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
01 Jul 2021
01 Jul 2021
Historique:
received:
04
06
2021
revised:
27
06
2021
accepted:
29
06
2021
entrez:
19
7
2021
pubmed:
20
7
2021
medline:
20
7
2021
Statut:
epublish
Résumé
Sex differences in the risk of Alzheimer's Disease (AD) in adults with Down Syndrome (DS) have not been extensively investigated, and existing studies have found conflicting results. This study examined the effect of sex on the risk of AD in adults with DS, adjusted for covariates. Adults with DS were assessed longitudinally for the development of AD. Competing risk survival analyses were used to determine the effect of sex alone and after adjustment for Sex differences were significant only in adults over 60 years of age, where men with DS were 6.32 (95% CI: 2.11-18.96, There is an age-associated effect of sex on the risk of AD, with men over 60 years old having six times the risk of AD compared with age-matched women, independent of
Sections du résumé
BACKGROUND
BACKGROUND
Sex differences in the risk of Alzheimer's Disease (AD) in adults with Down Syndrome (DS) have not been extensively investigated, and existing studies have found conflicting results. This study examined the effect of sex on the risk of AD in adults with DS, adjusted for covariates.
METHODS
METHODS
Adults with DS were assessed longitudinally for the development of AD. Competing risk survival analyses were used to determine the effect of sex alone and after adjustment for
RESULTS
RESULTS
Sex differences were significant only in adults over 60 years of age, where men with DS were 6.32 (95% CI: 2.11-18.96,
CONCLUSIONS
CONCLUSIONS
There is an age-associated effect of sex on the risk of AD, with men over 60 years old having six times the risk of AD compared with age-matched women, independent of
Identifiants
pubmed: 34279450
pii: jcm10132966
doi: 10.3390/jcm10132966
pmc: PMC8268850
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIA NIH HHS
ID : P30 AG066462
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Organisme : NIH HHS
ID : R01AG014673
Pays : United States
Organisme : NIA NIH HHS
ID : P01HD035897
Pays : United States
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