Nonribosomal peptide synthetases and their biotechnological potential in Penicillium rubens.
Antibiotics
Natural products
Nonribosomal peptide synthetases
Journal
Journal of industrial microbiology & biotechnology
ISSN: 1476-5535
Titre abrégé: J Ind Microbiol Biotechnol
Pays: Germany
ID NLM: 9705544
Informations de publication
Date de publication:
24 Aug 2021
24 Aug 2021
Historique:
accepted:
12
07
2021
received:
10
04
2021
pubmed:
20
7
2021
medline:
26
11
2021
entrez:
19
7
2021
Statut:
ppublish
Résumé
Nonribosomal peptide synthetases (NRPS) are large multimodular enzymes that synthesize a diverse variety of peptides. Many of these are currently used as pharmaceuticals, thanks to their activity as antimicrobials (penicillin, vancomycin, daptomycin, echinocandin), immunosuppressant (cyclosporin) and anticancer compounds (bleomycin). Because of their biotechnological potential, NRPSs have been extensively studied in the past decades. In this review, we provide an overview of the main structural and functional features of these enzymes, and we consider the challenges and prospects of engineering NRPSs for the synthesis of novel compounds. Furthermore, we discuss secondary metabolism and NRP synthesis in the filamentous fungus Penicillium rubens and examine its potential for the production of novel and modified β-lactam antibiotics.
Identifiants
pubmed: 34279620
pii: 6324005
doi: 10.1093/jimb/kuab045
pmc: PMC8788816
pii:
doi:
Substances chimiques
Peptide Synthases
EC 6.3.2.-
non-ribosomal peptide synthase
EC 6.3.2.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Groningen
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of Society of Industrial Microbiology and Biotechnology.
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