A prospective evaluation of lung function at three and six months in patients with previous SARS-COV-2 pneumonia.
COVID-19
Lung function
Pneumonia
SARS-CoV2
Spirometry
Journal
Respiratory medicine
ISSN: 1532-3064
Titre abrégé: Respir Med
Pays: England
ID NLM: 8908438
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
10
04
2021
revised:
11
06
2021
accepted:
08
07
2021
pubmed:
20
7
2021
medline:
9
10
2021
entrez:
19
7
2021
Statut:
ppublish
Résumé
This study investigated the consequences of Coronavirus Disease 2019 (COVID-19) pneumonia on lung function in the first 6 months after hospital discharge. A prospective lung function assessment in SARS-CoV2 patients with COVID-19 pneumonia, hospitalized between March and April 2020, was conducted with spirometry measurements including lung volumes, mainly total lung capacity (TLC), lung diffusion capacity for carbon monoxide (DL Among 40 consecutive patients, 19 (48%) had normal pulmonary functional tests (group A), and 21 (52%) showed residual lung function abnormalities at 3 months after hospital discharge (group B). In group B, 4 patients (19%) had only loss of lung volume as shown by TLC reduction (group 1), 13 patients (62%) had decreased both TLC and DL Nearly 50% of patients recovered in the post-critical phase. Most of those with abnormal pulmonary function tests at 3 months improved subsequently, but only another 29% (6 out of 21) reached normal values at 6 months. These results indicate that lung function spontaneous recovery is faster at first and occurs more slowly thereafter, leaving more than one third (15 out of 40) of patients with abnormal lung function tests at 6 months.
Identifiants
pubmed: 34280885
pii: S0954-6111(21)00247-X
doi: 10.1016/j.rmed.2021.106541
pmc: PMC8272067
pii:
doi:
Substances chimiques
Biosimilar Pharmaceuticals
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
106541Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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