Slowly resorbable biosynthetic mesh: 2-year results in VHWG grade 3 hernia repair.

Adult Hernia, Ventral / etiology Herniorrhaphy / adverse effects Humans Incisional Hernia / surgery Prospective Studies Quality of Life Recurrence Surgical Mesh / adverse effects Treatment Outcome
Biosynthetic mesh Hernia recurrence Hernia surgery Incisional hernia

Journal

Hernia : the journal of hernias and abdominal wall surgery
ISSN: 1248-9204
Titre abrégé: Hernia
Pays: France
ID NLM: 9715168

Informations de publication

Date de publication:
02 2022
Historique:
received: 20 04 2021
accepted: 27 06 2021
pubmed: 21 7 2021
medline: 3 5 2022
entrez: 20 7 2021
Statut: ppublish

Résumé

Information on the long-term performance of biosynthetic meshes is scarce. This study analyses the performance of biosynthetic mesh (Phasix™) over 24 months. A prospective, international European multi-center trial is described. Adult patients with a Ventral Hernia Working Group (VHWG) grade 3 incisional hernia larger than 10 cm Eighty-four patients were treated with biosynthetic mesh. Twenty-two patients (26.2%) developed 34 SSOs, of which 32 occurred within 3 months (primary endpoint). Eight patients (11.0%) developed a hernia recurrence. In 13 patients (15.5%), 14 reoperations took place, of which 6 were performed for hernia recurrence (42.9%), 3 for mesh infection (21.4%), and in 7 of which the mesh was explanted (50%). Compared to baseline, quality of life outcomes showed no significant difference after 24 months. Despite theoretical resorption, 10.7% of patients reported presence of mesh sensation in daily life 24 months after surgery. After 2 years of follow-up, hernia repair with biosynthetic mesh shows manageable SSO rates and favorable recurrence rates in VHWG grade 3 patients. No statistically significant improvement in quality of life or reduction of pain was observed. Few patients report lasting presence of mesh sensation. Results of biosynthetic mesh after longer periods of follow-up on recurrences and remodeling will provide further valuable information to make clear recommendations. Registered on clinicaltrials.gov (NCT02720042), March 25, 2016.

Identifiants

DOI: 10.1007/s10029-021-02453-1 PMID: 34282506 PMC: PMC8881263
pubmed: 34282506
doi: 10.1007/s10029-021-02453-1
pii: 10.1007/s10029-021-02453-1
pmc: PMC8881263
doi:

Banques de données

ClinicalTrials.gov
['NCT02720042']

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

131-138

Informations de copyright

© 2021. The Author(s).

Références

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Auteurs

M M J Van Rooijen (MMJ)

Department of Surgery, Erasmus University Medical Centre Rotterdam, Room Ee-1453, PO BOX 2040, 3000 CA, Rotterdam, The Netherlands. m.vanrooijen@erasmusmc.nl.
ORCID: 0000-0002-1037-6883

T Tollens (T)

Department of General Surgery, Imelda Hospital, Bonheiden, Belgium.

L N Jørgensen (LN)

Department of Surgery, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

T S de Vries Reilingh (TS)

Department of Surgery, Elkerliek Hospital, Helmond, The Netherlands.

G Piessen (G)

Department of Surgery, University Hospital Lille, Lille, France.

F Köckerling (F)

Department of Surgery, Vivantes Klinikum Spandau, Berlin, Germany.

M Miserez (M)

Department of Abdominal Surgery, University Hospital Leuven, Leuven, Belgium.

A C J Windsor (ACJ)

Department of Colorectal Surgery, University College London Hospital, London, UK.

F Berrevoet (F)

Department of General and Hepatobiliary Surgery, University Hospital Ghent, Ghent, Belgium.

R H Fortelny (RH)

Department of General, Visceral and Oncologic Surgery, Wilhelminen Hospital, Vienna, Austria.

B Dousset (B)

Department of Digestive, Hepatobiliary and Endocrine Surgery, Hôpital Cochin, Paris, France.

G Woeste (G)

Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

H L van Westreenen (HL)

Department of Surgery, Isala Zwolle, Zwolle, The Netherlands.

F Gossetti (F)

Università di Roma Sapienza, Rome, Italy.

J F Lange (JF)

Department of Surgery, Erasmus University Medical Centre Rotterdam, Room Ee-1453, PO BOX 2040, 3000 CA, Rotterdam, The Netherlands.
Department of Surgery, IJsselland Ziekenhuis, Capelle aan den Ijssel, The Netherlands.

G W M Tetteroo (GWM)

Department of Surgery, IJsselland Ziekenhuis, Capelle aan den Ijssel, The Netherlands.

A Koch (A)

Chirurgische Praxis Cottbus, Cottbus, Germany.

J Jeekel (J)

Department of Neuroscience, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Slowly resorbable biosynthetic mesh: 2-year...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Hernie › Hernie abdominale › Hernie ventrale › Slowly resorbable biosynthetic mesh: 2-year...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie reconstructive › Herniorraphie › Slowly resorbable biosynthetic mesh: 2-year...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Slowly resorbable biosynthetic mesh: 2-year...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Hernie incisionnelle › Slowly resorbable biosynthetic mesh: 2-year...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Slowly resorbable biosynthetic mesh: 2-year...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Slowly resorbable biosynthetic mesh: 2-year...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Récidive › Slowly resorbable biosynthetic mesh: 2-year...
questionsmedicales.fr › Équipement et fournitures › Équipement chirurgical › Filet chirurgical › Slowly resorbable biosynthetic mesh: 2-year...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Slowly resorbable biosynthetic mesh: 2-year...