The ROMANOV study found impaired humoral and cellular immune responses to SARS-CoV-2 mRNA vaccine in virus-unexposed patients receiving maintenance hemodialysis.

Antibodies, Viral BNT162 Vaccine CD8-Positive T-Lymphocytes COVID-19 COVID-19 Vaccines Humans Immunity, Cellular RNA, Messenger Renal Dialysis / adverse effects SARS-CoV-2
BNT162b2 COVID-19 SARS-CoV-2 hemodialysis mRNA vaccine

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
10 2021
Historique:
received: 09 04 2021
revised: 24 06 2021
accepted: 01 07 2021
pubmed: 21 7 2021
medline: 29 9 2021
entrez: 20 7 2021
Statut: ppublish

Résumé

Patients on maintenance hemodialysis (MHD), which are at high risk of infection by SARS-CoV-2 virus and death due to COVID-19, have been prioritized for vaccination. However, because they were excluded from pivotal studies and have weakened immune responses, it is not known whether these patients are protected after the "standard" two doses of mRNA vaccines. To answer this, anti-spike receptor binding domain (RBD) IgG and interferon gamma-producing CD4

Identifiants

DOI: 10.1016/j.kint.2021.07.005 PMID: 34284044 PMC: PMC8286235
pubmed: 34284044
pii: S0085-2538(21)00679-7
doi: 10.1016/j.kint.2021.07.005
pmc: PMC8286235
pii:
doi:

Substances chimiques

Antibodies, Viral 0
COVID-19 Vaccines 0
RNA, Messenger 0
BNT162 Vaccine N38TVC63NU

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

928-936

Informations de copyright

Copyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Auteurs

Maxime Espi (M)

International Center for Infectiology Research (CIRI), French Institute of Health and Medical Research (INSERM) U1111, Université Claude Bernard Lyon I, National Center for Scientific Research (CNRS) Mixed Research Unit (UMR) 5308, Ecole Normale Supérieure de Lyon, University Lyon, Lyon, France; Department of Nephrology, Nutrition and Hemodialysis, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.

Xavier Charmetant (X)

International Center for Infectiology Research (CIRI), French Institute of Health and Medical Research (INSERM) U1111, Université Claude Bernard Lyon I, National Center for Scientific Research (CNRS) Mixed Research Unit (UMR) 5308, Ecole Normale Supérieure de Lyon, University Lyon, Lyon, France.

Thomas Barba (T)

International Center for Infectiology Research (CIRI), French Institute of Health and Medical Research (INSERM) U1111, Université Claude Bernard Lyon I, National Center for Scientific Research (CNRS) Mixed Research Unit (UMR) 5308, Ecole Normale Supérieure de Lyon, University Lyon, Lyon, France; Department of Internal Medicine, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France; Claude Bernard University (Lyon 1), Villeurbanne, France.

Laetitia Koppe (L)

Department of Nephrology, Nutrition and Hemodialysis, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France; Claude Bernard University (Lyon 1), Villeurbanne, France.

Caroline Pelletier (C)

Department of Nephrology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France.

Emilie Kalbacher (E)

Department of Nephrology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France.

Elodie Chalencon (E)

Department of Nephrology, Nutrition and Hemodialysis, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.

Virginie Mathias (V)

International Center for Infectiology Research (CIRI), French Institute of Health and Medical Research (INSERM) U1111, Université Claude Bernard Lyon I, National Center for Scientific Research (CNRS) Mixed Research Unit (UMR) 5308, Ecole Normale Supérieure de Lyon, University Lyon, Lyon, France; Human Leukocyte Antigen Laboratory, French National Blood Service, Décines-Charpieu, France.

Anne Ovize (A)

Eurofins Biomnis Laboratory, Lyon, France.

Emmanuelle Cart-Tanneur (E)

Eurofins Biomnis Laboratory, Lyon, France.

Christine Bouz (C)

Eurofins Biomnis Laboratory, Lyon, France.

Laurence Pellegrina (L)

Eurofins Biomnis Laboratory, Lyon, France.

Emmanuel Morelon (E)

Claude Bernard University (Lyon 1), Villeurbanne, France; Department of Transplantation, Nephrology and Clinical Immunology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France.

Denis Fouque (D)

Department of Nephrology, Nutrition and Hemodialysis, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France; Claude Bernard University (Lyon 1), Villeurbanne, France.

Laurent Juillard (L)

Claude Bernard University (Lyon 1), Villeurbanne, France; Department of Nephrology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France.

Olivier Thaunat (O)

International Center for Infectiology Research (CIRI), French Institute of Health and Medical Research (INSERM) U1111, Université Claude Bernard Lyon I, National Center for Scientific Research (CNRS) Mixed Research Unit (UMR) 5308, Ecole Normale Supérieure de Lyon, University Lyon, Lyon, France; Claude Bernard University (Lyon 1), Villeurbanne, France; Department of Transplantation, Nephrology and Clinical Immunology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France. Electronic address: olivier.thaunat@chu-lyon.fr.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › The ROMANOV study found impaired humoral and...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Vaccins synthétiques › Vaccins à base d'acide nucléique › Vaccins à ARNm › Vaccin BNT162 › The ROMANOV study found impaired humoral and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › The ROMANOV study found impaired humoral and...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › The ROMANOV study found impaired humoral and...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre la COVID-19 › The ROMANOV study found impaired humoral and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The ROMANOV study found impaired humoral and...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité cellulaire › The ROMANOV study found impaired humoral and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › The ROMANOV study found impaired humoral and...
questionsmedicales.fr › Thérapeutique › Détoxication par sorption › Dialyse rénale › The ROMANOV study found impaired humoral and...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › The ROMANOV study found impaired humoral and...