Near-infrared light-responsive liposomes for protein delivery: Towards bleeding-free photothermally-assisted thrombolysis.

Doxorubicin Drug Delivery Systems Gold Infrared Rays Liposomes Thrombolytic Therapy
Drug release Gold nanorods Light-responsive liposomes Photothermally-assisted thrombolysis Urokinase liposomes uPA

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
10 09 2021
Historique:
received: 15 04 2021
revised: 11 07 2021
accepted: 14 07 2021
pubmed: 21 7 2021
medline: 29 10 2021
entrez: 20 7 2021
Statut: ppublish

Résumé

Smart drug delivery systems represent state-of-the-art approaches for targeted therapy of life-threatening diseases such as cancer and cardiovascular diseases. Stimuli-responsive on-demand release of therapeutic agents at the diseased site can significantly limit serious adverse effects. In this study, we engineered a near-infrared (NIR) light-responsive liposomal gold nanorod-containing platform for on-demand delivery of proteins using a hybrid formulation of ultrasmall gold nanorods (AuNRs), thermosensitive phospholipid (DPPC) and non-ionic surfactant (Brij58). In light-triggered release optimization studies, 55.6% (± 4.8) of a FITC-labelled model protein, ovalbumin (MW 45 kDa) was released in 15 min upon NIR irradiation (785 nm, 1.35 W/cm

Identifiants

DOI: 10.1016/j.jconrel.2021.07.024 PMID: 34284049
pubmed: 34284049
pii: S0168-3659(21)00367-9
doi: 10.1016/j.jconrel.2021.07.024
pii:
doi:

Substances chimiques

Liposomes 0
Gold 7440-57-5
Doxorubicin 80168379AG

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

212-223

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Ahmed Refaat (A)

Department of Telecommunications, Electrical, Robotics and Biomedical Engineering, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Melbourne, VIC 3122, Australia; Atherothrombosis and Vascular Biology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Molecular Imaging and Theranostics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Pharmaceutics Department, Faculty of Pharmacy, Alexandria University, 21021, Egypt.

Blanca Del Rosal (B)

ARC Centre of Excellence for Nanoscale BioPhotonics, School of Science, RMIT University, Melbourne, VIC 3000, Australia.

Jathushan Palasubramaniam (J)

Atherothrombosis and Vascular Biology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Molecular Imaging and Theranostics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Department of Medicine, Monash University, Melbourne, VIC 3800, Australia; Department of Cardiology, Alfred Hospital, Melbourne, VIC 3004, Australia.

Geoffrey Pietersz (G)

Atherothrombosis and Vascular Biology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Burnet Institute, Melbourne, VIC 3004, Australia.

Xiaowei Wang (X)

Atherothrombosis and Vascular Biology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Molecular Imaging and Theranostics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Department of Medicine, Monash University, Melbourne, VIC 3800, Australia; Department of Cardiometabolic Health, University of Melbourne, VIC 3010, Australia.

Simon E Moulton (SE)

Department of Telecommunications, Electrical, Robotics and Biomedical Engineering, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Melbourne, VIC 3122, Australia; Iverson Health Innovation Research Institute, Swinburne University of Technology, Melbourne, VIC 3122, Australia; ARC Centre of Excellence for Electromaterials Science, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Melbourne, VIC 3122, Australia; Aikenhead Centre for Medical Discovery (ACMD), St Vincent's Hospital, Melbourne, VIC 3065, Australia; Australian Institute for Innovative Materials, Intelligent Polymer Research Institute, University of Wollongong, Wollongong, NSW 2500, Australia. Electronic address: smoulton@swin.edu.au.

Karlheinz Peter (K)

Atherothrombosis and Vascular Biology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Department of Medicine, Monash University, Melbourne, VIC 3800, Australia; Department of Cardiology, Alfred Hospital, Melbourne, VIC 3004, Australia; Department of Cardiometabolic Health, University of Melbourne, VIC 3010, Australia. Electronic address: karlheinz.peter@baker.edu.au.

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Classifications MeSH

questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › Near-infrared light-responsive liposomes for...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Near-infrared light-responsive liposomes for...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Or › Near-infrared light-responsive liposomes for...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons infrarouges › Near-infrared light-responsive liposomes for...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Near-infrared light-responsive liposomes for...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitement thrombolytique › Near-infrared light-responsive liposomes for...