Giant plurihormonal pituitary adenoma in a child - case study.
CNS tumor
plurihormonal pituitary adenoma
sella turcica
Journal
Journal of pediatric endocrinology & metabolism : JPEM
ISSN: 2191-0251
Titre abrégé: J Pediatr Endocrinol Metab
Pays: Germany
ID NLM: 9508900
Informations de publication
Date de publication:
25 Nov 2021
25 Nov 2021
Historique:
received:
19
03
2021
accepted:
29
06
2021
pubmed:
21
7
2021
medline:
25
2
2022
entrez:
20
7
2021
Statut:
epublish
Résumé
To describe the case of a 12-year-old girl with a rare plurihormonal pituitary macroadenoma secreting prolactin (PRL), growth hormone (GH), thyroid-stimulating hormone (TSH), and alpha subunit (α-SU). The patient experienced recurrent headaches and progressing loss of vision in one eye. During the examination, abnormalities such as tall stature, coarse facial features, enlarged feet and hands, tachycardia, hand tremor, hyperhidrosis, galactorrhea, and goiter were observed. Head magnetic resonance imaging (MRI) revealed a solid tumor in the anterior and middle cranial fossa, measuring 80 × 50 × 55 mm. A stereotactic biopsy revealed plurihormonal Pit-1 positive pituitary adenoma secreting PRL, GH, and TSH. A pituitary hyperfunction with PRL, GH, TSH, and α-SU excess was diagnosed. The patient was successfully treated pharmacologically with dopamine agonists and somatostatin analogue, and a decrease of tumor volume (30%) was achieved. When neurosurgery is not possible, long-term pharmacological treatment of plurihormonal pituitary macroadenoma can be a safe and relatively effective alternative.
Identifiants
pubmed: 34284528
pii: jpem-2021-0094
doi: 10.1515/jpem-2021-0094
doi:
Substances chimiques
Human Growth Hormone
12629-01-5
Prolactin
9002-62-4
Thyrotropin
9002-71-5
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1469-1473Informations de copyright
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
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