Methyl donor micronutrients, CD40-ligand methylation and disease activity in systemic lupus erythematosus: A cross-sectional association study.
CD40-ligand
Systemic lupus erythematosus
T-cells
disease activity
methylation
nutrition
Journal
Lupus
ISSN: 1477-0962
Titre abrégé: Lupus
Pays: England
ID NLM: 9204265
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
pubmed:
22
7
2021
medline:
9
2
2022
entrez:
21
7
2021
Statut:
ppublish
Résumé
Hypomethylation of CD40-ligand (CD40L) in T-cells is associated with increased disease activity in systemic lupus erythematosus (SLE). We therefore investigated possible associations of dietary methyl donors and products with CD40L methylation status in SLE. Food frequency questionnaires were employed to calculate methyl donor micronutrients in 61 female SLE patients (age 45.7 ± 12.0 years, disease duration 16.2 ± 8.4 years) and compared to methylation levels of previously identified key DNA methylation sites (CpG17 and CpG22) within CD40L promotor of T-cells using quantitative DNA methylation analysis on the EpiTYPER mass spectrometry platform. Disease activity was assessed by SLE Disease Activity Index (SLEDAI). Linear regression modelling was used. P values were adjusted according to Benjamini & Hochberg. Amongst the micronutrients assessed (g per day), methionine and cysteine were associated with methylation of CpG17 (β = 5.0 (95%CI: 0.6-9.4), p = 0.04; and β = 2.4 (0.6-4.1), p = 0.02, respectively). Methionine, choline, and cysteine were additionally associated with the mean methylation of the entire Dietary methyl donors may influence DNA methylation levels and thereby disease activity in SLE.
Identifiants
pubmed: 34284675
doi: 10.1177/09612033211034559
pmc: PMC8564257
doi:
Substances chimiques
Micronutrients
0
CD40 Ligand
147205-72-9
Methionine
AE28F7PNPL
Cysteine
K848JZ4886
Choline
N91BDP6H0X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1773-1780Références
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