Changes in the Biomarkers of Oxidative/Nitrosative Stress and Endothelial Dysfunction Are Associated with Cardiovascular Risk in Periodontitis Patients.
3-nitrotyrosine (NT)
asymmetric dimethylarginine (ADMA)
cardiovascular disease
coenzyme Q10 (CoQ10)
inflammasome
periodontitis (PT)
peripheral blood mononuclear cells (PBMC)
Journal
Current issues in molecular biology
ISSN: 1467-3045
Titre abrégé: Curr Issues Mol Biol
Pays: Switzerland
ID NLM: 100931761
Informations de publication
Date de publication:
15 Jul 2021
15 Jul 2021
Historique:
received:
15
06
2021
revised:
08
07
2021
accepted:
13
07
2021
entrez:
21
7
2021
pubmed:
22
7
2021
medline:
28
12
2021
Statut:
epublish
Résumé
Patients with cardiovascular disease (CVD) and periodontitis (PT) show shared risk factors as result of the altered molecular mechanisms associated with pathological conditions. The aim of our study was to evaluate if the plasma biomarkers associated with endothelial dysfunction may also be related to alterations in the inflammatory status in peripheral blood mononuclear cells (PBMC). Patients with PT, coronary heart disease (CHD), or both diseases as well as controls were enrolled. Plasma levels of coenzyme Q10 (CoQ10), 3-nitrotyrosine (NT), and asymmetric dimethylarginine (ADMA) were assessed using HPLC. mRNA levels of caspase-1 (
Identifiants
pubmed: 34287264
pii: cimb43020051
doi: 10.3390/cimb43020051
pmc: PMC8929118
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
704-715Références
Clin Interv Aging. 2018 Apr 26;13:757-772
pubmed: 29731617
Int J Mol Sci. 2014 Jul 02;15(7):11773-82
pubmed: 24992596
Oxid Med Cell Longev. 2020 Apr 14;2020:4293206
pubmed: 32377298
J Periodontol. 2020 Jan 7;:
pubmed: 31912509
Biomedicines. 2020 Aug 06;8(8):
pubmed: 32781796
Essays Biochem. 2020 Feb 17;64(1):111-133
pubmed: 32016371
Front Physiol. 2017 Nov 13;8:910
pubmed: 29180965
Dis Markers. 2015;2015:708282
pubmed: 25814781
Compr Rev Food Sci Food Saf. 2020 Mar;19(2):574-594
pubmed: 33325173
Am J Respir Cell Mol Biol. 2007 May;36(5):520-8
pubmed: 17158357
N Engl J Med. 2003 Jul 3;349(1):60-72
pubmed: 12840094
Circulation. 2012 Aug 7;126(6):753-67
pubmed: 22869857
J Exp Med. 2011 Mar 14;208(3):417-20
pubmed: 21357740
Eur J Oral Sci. 2001 Feb;109(1):2-7
pubmed: 11330929
Redox Biol. 2015;4:296-307
pubmed: 25625584
Circulation. 2004 Jun 1;109(21 Suppl 1):II2-10
pubmed: 15173056
J Cereb Blood Flow Metab. 2016 Jan;36(1):72-94
pubmed: 26058695
Exp Physiol. 1997 Mar;82(2):291-5
pubmed: 9129943
Oxid Med Cell Longev. 2020 Feb 17;2020:4063562
pubmed: 32148650
Eur Heart J. 2015 Feb 21;36(8):482-9c
pubmed: 25433021
Front Physiol. 2021 Jan 14;11:609614
pubmed: 33519515
Int J Mol Sci. 2020 Oct 23;21(21):
pubmed: 33114148
Mol Syndromol. 2014 Jul;5(3-4):187-97
pubmed: 25126052
Cochrane Database Syst Rev. 2017 Nov 07;11:CD009197
pubmed: 29112241
Dis Markers. 2020 Jun 12;2020:1215802
pubmed: 32626540
Circulation. 2012 Nov 13;126(20):2371-3
pubmed: 23081988
Thromb Haemost. 2002 Oct;88(4):554-67
pubmed: 12362224
Curr Cardiol Rev. 2010 May;6(2):82-90
pubmed: 21532773
Oxid Med Cell Longev. 2018 Dec 2;2018:9421019
pubmed: 30622677
J Clin Med. 2020 Jul 23;9(8):
pubmed: 32718053
Eur Rev Med Pharmacol Sci. 2020 Jun;24(12):6939-6948
pubmed: 32633387
Drug Discov Ther. 2019;13(1):38-46
pubmed: 30880321
J Physiol. 2004 Jul 1;558(Pt 1):239-48
pubmed: 15133063
Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):978-985
pubmed: 29450537
Oxid Med Cell Longev. 2020 Oct 30;2020:8819719
pubmed: 33204398
Antioxid Redox Signal. 2014 Mar 1;20(7):1126-67
pubmed: 23991888
Curr Cardiol Rev. 2018;14(3):164-174
pubmed: 29663894