Real-time cognitive performance and positive symptom expression in schizophrenia.
Cognitive functions
Ecological Momentary Assessment
Graph theory
Magnetic resonance imaging
Positive symptoms
Schizophrenia
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
28
10
2020
accepted:
04
07
2021
pubmed:
22
7
2021
medline:
7
4
2022
entrez:
21
7
2021
Statut:
ppublish
Résumé
Deficits in cognitive functions are frequent in schizophrenia and are often conceptualized as stable characteristics of this disorder. However, cognitive capacities may fluctuate over the course of a day and it is unknown if such variation may be linked to the dynamic expression of psychotic symptoms. This investigation used Ecological Momentary Assessment (EMA) to provide mobile tests of cognitive functions and positive symptoms in real time. Thirty-three individuals with schizophrenia completed five EMA assessments per day for a one-week period that included real-time assessments of cognitive performance and psychotic symptoms. A subsample of patients and 31 healthy controls also completed a functional MRI examination. Relative to each individual's average score, moments of worsened cognitive performance on the mobile tests were associated with an increased probability of positive symptom occurrence over subsequent hours of the day (coef = 0.06, p < 0.05), adjusting for the presence of psychotic symptoms at the moment of mobile test administration. These prospective associations varied as a function of graph theory indices in MRI analyses. These findings demonstrate that cognitive performance is prospectively linked to psychotic symptom expression in daily life, and that underlying brain markers may be observed in the Executive Control Network. While the potential causal nature of this association remains to be investigated, our results offer promising prospects for a better understanding of the underlying mechanisms of symptom expression in schizophrenia.
Identifiants
pubmed: 34287696
doi: 10.1007/s00406-021-01296-2
pii: 10.1007/s00406-021-01296-2
pmc: PMC8938338
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
415-425Subventions
Organisme : the Agence Nationale de la Recherche
ID : ANR-12-BSH2-0012
Organisme : Fondation pour la Recherche Médicale
ID : DPA20140629807
Informations de copyright
© 2021. The Author(s).
Références
J Neurosci. 2010 Jul 14;30(28):9477-87
pubmed: 20631176
Front Neuroinform. 2014 Feb 21;8:14
pubmed: 24600388
Schizophr Res. 2009 Sep;113(2-3):189-99
pubmed: 19628375
Neuroimage. 2012 Oct 1;62(4):2296-314
pubmed: 22387165
Med Image Anal. 2008 Feb;12(1):26-41
pubmed: 17659998
Neuroimage. 2015 May 15;112:267-277
pubmed: 25770991
Nat Rev Neurosci. 2007 Sep;8(9):700-11
pubmed: 17704812
Neurosci Biobehav Rev. 2011 Apr;35(5):1110-24
pubmed: 21115039
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
Clin Neurosci. 1995;3(2):89-97
pubmed: 7583624
Neuroimage. 2012 Feb 1;59(3):2196-207
pubmed: 22008374
PLoS One. 2011;6(9):e25423
pubmed: 21980454
Neuropsychol Rev. 2014 Mar;24(1):32-48
pubmed: 24500505
Front Hum Neurosci. 2012 May 23;6:137
pubmed: 22654746
Schizophr Res. 2013 Jul;147(2-3):339-47
pubmed: 23706416
Psychol Bull. 2009 Jan;135(1):157-71
pubmed: 19210058
IEEE Trans Med Imaging. 2001 Jan;20(1):45-57
pubmed: 11293691
Philos Trans R Soc Lond B Biol Sci. 2014 Oct 5;369(1653):
pubmed: 25180301
Nat Methods. 2019 Jan;16(1):111-116
pubmed: 30532080
Schizophr Bull. 2009 May;35(3):509-27
pubmed: 19155345
Hum Brain Mapp. 2009 Feb;30(2):403-16
pubmed: 18072237
JAMA Psychiatry. 2017 May 1;74(5):528-534
pubmed: 28355471
Schizophr Bull. 2017 Jul 1;43(4):754-763
pubmed: 28177507
Neuroimage. 2017 May 15;152:437-449
pubmed: 28167349
Dialogues Clin Neurosci. 2005;7(2):165-79
pubmed: 16262211
Schizophr Res. 2018 Mar;193:336-342
pubmed: 28689754
Neuroimage. 2003 Oct;20(2):870-88
pubmed: 14568458
Schizophr Bull. 1987;13(2):261-76
pubmed: 3616518
Schizophr Res. 1997 Dec 19;28(2-3):143-56
pubmed: 9468349
Psychol Med. 2009 Mar;39(3):381-92
pubmed: 18588741
Br J Psychiatry. 2010 Jun;196(6):447-53
pubmed: 20513854
Schizophr Bull. 2011 Nov;37(6):1248-56
pubmed: 20427351
Front Syst Neurosci. 2010 Oct 08;4:147
pubmed: 21031030
Magn Reson Med. 1995 Oct;34(4):537-41
pubmed: 8524021
Schizophr Bull. 1998;24(2):203-18
pubmed: 9613621
Comput Biomed Res. 1996 Jun;29(3):162-73
pubmed: 8812068
IEEE Trans Med Imaging. 2010 Jun;29(6):1310-20
pubmed: 20378467
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
Acta Psychiatr Scand. 2018 Dec;138(6):558-570
pubmed: 30203454
Front Syst Neurosci. 2012 Jan 10;5:103
pubmed: 22275887
Psychiatry Res Neuroimaging. 2017 Dec 30;270:22-31
pubmed: 29017061
Transl Psychiatry. 2020 Apr 27;10(1):122
pubmed: 32341335
Neuroimage. 2009 Oct 15;48(1):63-72
pubmed: 19573611
Am J Psychiatry. 2011 Feb;168(2):202-9
pubmed: 21078705
Eur J Neurosci. 2017 Nov;46(9):2471-2480
pubmed: 28922510
Schizophr Bull. 2012 May;38(3):475-85
pubmed: 20841326
Dialogues Clin Neurosci. 2013 Sep;15(3):339-49
pubmed: 24174905
Schizophr Bull. 2008 May;34(3):507-14
pubmed: 17932087
World Psychiatry. 2012 Oct;11(3):196-8
pubmed: 23024681
Front Syst Neurosci. 2010 Jun 07;4:16
pubmed: 20589099
Brain. 2008 Apr;131(Pt 4):945-61
pubmed: 18299296
Schizophr Res. 1998 Mar 10;30(2):115-25
pubmed: 9549774
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
Int J Methods Psychiatr Res. 2017 Dec;26(4):
pubmed: 28370881