Synthesis and Antimicrobial Evaluation of Bis-morpholine Triazine Quaternary Ammonium Salts.
Anti-Bacterial Agents
/ chemical synthesis
Dose-Response Relationship, Drug
Escherichia coli
/ drug effects
Microbial Sensitivity Tests
Molecular Structure
Morpholines
/ chemistry
Quaternary Ammonium Compounds
/ chemistry
Salts
/ chemistry
Staphylococcus aureus
/ drug effects
Structure-Activity Relationship
Triazines
/ chemistry
QAS
antimicrobial agents
low toxicity antimicrobials
triazine quaternary ammonium salts
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
revised:
18
07
2021
received:
07
06
2021
pubmed:
22
7
2021
medline:
24
2
2022
entrez:
21
7
2021
Statut:
ppublish
Résumé
Efficient, environmentally and economically sustainable, and nontoxic antibacterial products are of global relevance in the fight against microorganism contamination. In this work, an easy and straightforward method for the synthesis of bis-morpholino triazine quaternary ammonium salts (bis-mTQAS) is reported, starting from 2,4,6-trichloro-1,3,5-triazine or 2,4-dichloro-6-methoxy-1,3,5-triazine and various N-alkylmorpholines. Bis-mTQAS were tested as antimicrobials against Gram-negative and Gram-positive bacterial strains. The best-performing bis-mTQAS were found to achieve total disinfection against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 at 50 and 400 μg/mL, respectively. Distinctively, bis-mTQAS with the highest antimicrobial efficiency had lowest cytotoxicity.
Identifiants
pubmed: 34288499
doi: 10.1002/cmdc.202100409
pmc: PMC8596621
doi:
Substances chimiques
Anti-Bacterial Agents
0
Morpholines
0
Quaternary Ammonium Compounds
0
Salts
0
Triazines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3172-3176Informations de copyright
© 2021 The Authors. ChemMedChem published by Wiley-VCH GmbH.
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