Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation.
Analgesics
/ pharmacology
Animals
Anti-Anxiety Agents
/ pharmacology
Anxiety
/ physiopathology
Behavior, Animal
/ drug effects
Calcium
/ metabolism
Chronic Pain
/ pathology
Emotions
/ drug effects
Female
Gyrus Cinguli
/ drug effects
Interneurons
/ drug effects
Light
Long-Term Potentiation
/ drug effects
Male
Mice
Mice, Inbred C57BL
Microinjections
Nerve Tissue
/ drug effects
Neural Inhibition
/ drug effects
Neuralgia
/ complications
Oxytocin
/ administration & dosage
Paraventricular Hypothalamic Nucleus
/ drug effects
Presynaptic Terminals
/ drug effects
Receptors, G-Protein-Coupled
/ metabolism
Receptors, GABA-A
/ metabolism
Receptors, Oxytocin
/ genetics
Signal Transduction
/ drug effects
Synaptic Transmission
/ drug effects
Up-Regulation
/ drug effects
anterior cingulate cortex
anxiety
inhibitory transmission
long-term potentiation
neuropathic pain
oxytocin
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
20 07 2021
20 07 2021
Historique:
received:
13
07
2020
revised:
14
05
2021
accepted:
25
06
2021
entrez:
21
7
2021
pubmed:
22
7
2021
medline:
9
2
2022
Statut:
ppublish
Résumé
Oxytocin is a well-known neurohypophysial hormone that plays an important role in behavioral anxiety and nociception. Two major forms of long-term potentiation, presynaptic LTP (pre-LTP) and postsynaptic LTP (post-LTP), have been characterized in the anterior cingulate cortex (ACC). Both pre-LTP and post-LTP contribute to chronic-pain-related anxiety and behavioral sensitization. The roles of oxytocin in the ACC have not been studied. Here, we find that microinjections of oxytocin into the ACC attenuate nociceptive responses and anxiety-like behavioral responses in animals with neuropathic pain. Application of oxytocin selectively blocks the maintenance of pre-LTP but not post-LTP. In addition, oxytocin enhances inhibitory transmission and excites ACC interneurons. Similar results are obtained by using selective optical stimulation of oxytocin-containing projecting terminals in the ACC in animals with neuropathic pain. Our results demonstrate that oxytocin acts on central synapses and reduces chronic-pain-induced anxiety by reducing pre-LTP.
Identifiants
pubmed: 34289348
pii: S2211-1247(21)00824-X
doi: 10.1016/j.celrep.2021.109411
pii:
doi:
Substances chimiques
Analgesics
0
Anti-Anxiety Agents
0
Receptors, G-Protein-Coupled
0
Receptors, GABA-A
0
Receptors, Oxytocin
0
Oxytocin
50-56-6
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109411Subventions
Organisme : CIHR
ID : PJT-148648
Pays : Canada
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.