Process variations between Swiss units treating neonates with hypoxic-ischemic encephalopathy and their effect on short-term outcome.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
01
10
2020
accepted:
09
07
2021
revised:
28
05
2021
pubmed:
23
7
2021
medline:
19
2
2022
entrez:
22
7
2021
Statut:
ppublish
Résumé
To compare therapeutic hypothermia (TH) treatment of term and near-term neonates with hypoxic-ischemic encephalopathy (HIE) between neonatal units. Population-based, retrospective analysis of TH initiation and maintenance, and of diagnostic imaging. The comparison between units was based on crude data analysis, indirect standardization, and adjusted logistic regression. TH was provided to 570 neonates with HIE between 2011 and 2018 in 10 Swiss units. We excluded 121 off-protocol cooled neonates to avoid selection bias. Of the remaining 449 neonates, the outcome was favorable to international benchmarks, but there were large unit-to-unit variations in baseline perinatal data and TH management. A total of 5% neonates did not reach target temperature within 7 h (3-10% between units), and 29% experienced over- or undercooling (0-38%). Although the neonates had favorable short-term outcomes, areas for improvement remain for Swiss units in both process and outcome measures.
Identifiants
pubmed: 34290374
doi: 10.1038/s41372-021-01156-w
pii: 10.1038/s41372-021-01156-w
pmc: PMC8752440
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2804-2812Investigateurs
Dirk Bassler
(D)
Giancarlo Natalucci
(G)
Susanne Böttger
(S)
Bernhard Frey
(B)
Vera Bernet
(V)
Beate Grass
(B)
Bjarte Rogdo
(B)
Irene Hoigné
(I)
Martin Stocker
(M)
Thomas M Berger
(TM)
Matteo Fontana
(M)
Lukas Hegi
(L)
Philipp Meyer
(P)
Gabriel Konetzny
(G)
Sven M Schulzke
(SM)
Sven Wellmann
(S)
Maya Hug
(M)
Tilman Humpl
(T)
Bendicht Wagner
(B)
Karin Daetwyler
(K)
Thomas Riedel
(T)
Brigitte Scharrer
(B)
Nicolas Binz
(N)
Anita Truttmann
(A)
Juliane Schneider
(J)
Informations de copyright
© 2021. The Author(s).
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