Integrative bioinformatics approaches to map key biological markers and therapeutic drugs in Extramammary Paget's disease of the scrotum.

Biomarkers / metabolism Computational Biology Databases, Nucleic Acid Disease-Free Survival Gene Expression Profiling Gene Expression Regulation Genital Diseases, Male / drug therapy Humans Male Paget Disease, Extramammary / drug therapy Pharmaceutical Preparations Scrotum / metabolism Survival Rate

Journal

PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081

Informations de publication

Date de publication:
2021
Historique:
received: 21 04 2021
accepted: 30 06 2021
entrez: 22 7 2021
pubmed: 23 7 2021
medline: 11 11 2021
Statut: epublish

Résumé

Extramammary Paget's disease (EMPD) is an intra-epidermal adenocarcinoma. Till now, the mechanisms underlying the pathogenesis of scrotal EMPD is poorly known. This present study aims to explore the knowledge of molecular mechanism of scrotal EMPD by identifying the hub genes and candidate drugs using integrated bioinformatics approaches. Firstly, the microarray datasets (GSE117285) were downloaded from the GEO database and then analyzed using GEO2R in order to obtain differentially expressed genes (DEGs). Moreover, hub genes were identified on the basis of their degree of connectivity using Cytohubba plugin of cytoscape tool. Finally, GEPIA and DGIdb were used for the survival analysis and selection of therapeutic candidates, respectively. A total of 786 DEGs were identified, of which 10 genes were considered as hub genes on the basis of the highest degree of connectivity. After the survival analysis of ten hub genes, a total of 5 genes were found to be altered in EMPD patients. Furthermore, 14 drugs of CHEK1, CCNA2, and CDK1 were found to have therapeutic potential against EMPD. This study updates the information and yields a new perspective in the context of understanding the pathogenesis of EMPD. In future, hub genes and candidate drugs might be capable of improving the personalized detection and therapies for EMPD.

Identifiants

DOI: 10.1371/journal.pone.0254678 PMID: 34292991 PMC: PMC8297842
pubmed: 34292991
doi: 10.1371/journal.pone.0254678
pii: PONE-D-21-13187
pmc: PMC8297842
doi:

Substances chimiques

Biomarkers 0
Pharmaceutical Preparations 0

Types de publication

Journal Article Retracted Publication

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0254678

Commentaires et corrections

Type : ErratumIn
Type : RetractionIn

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

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Auteurs

Fatima Noor (F)

Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.

Muhammad Hamzah Saleem (MH)

College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.

Jen-Tsung Chen (JT)

Department of Life Sciences, National University of Kaohsiung, Kaohsiung, Taiwan.
ORCID: 0000-0002-3540-4449

Muhammad Rizwan Javed (MR)

Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.

Wafa Abdullah Al-Megrin (WA)

Biology Department, Faculty of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

Sidra Aslam (S)

Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Integrative bioinformatics approaches to map...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Integrative bioinformatics approaches to map...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Bases de données comme sujet › Bases de données factuelles › Bases de données génétiques › Bases de données d'acides nucléiques › Integrative bioinformatics approaches to map...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Survie sans rechute › Integrative bioinformatics approaches to map...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Integrative bioinformatics approaches to map...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Integrative bioinformatics approaches to map...
questionsmedicales.fr › Maladies urogénitales › Maladies urogénitales de l'homme › Maladies de l'appareil génital mâle › Integrative bioinformatics approaches to map...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Integrative bioinformatics approaches to map...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs canalaires, lobulaires et médullaires › Maladie de Paget extramammaire › Integrative bioinformatics approaches to map...
questionsmedicales.fr › Préparations pharmaceutiques › Integrative bioinformatics approaches to map...
questionsmedicales.fr › Appareil urogénital › Système génital › Système génital de l'homme › Scrotum › Integrative bioinformatics approaches to map...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Taux de survie › Integrative bioinformatics approaches to map...