Through the looking glass: milestones on the road towards mirroring life.

DNA Proteins RNA / chemistry Stereoisomerism
L-RNA bioengineering chirality d-peptide enantiomer mirror-image biology

Journal

Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674

Informations de publication

Date de publication:
11 2021
Historique:
received: 12 02 2021
revised: 05 06 2021
accepted: 18 06 2021
pubmed: 24 7 2021
medline: 2 4 2022
entrez: 23 7 2021
Statut: ppublish

Résumé

Naturally occurring DNA, RNA, and proteins predominantly exist in only one enantiomeric form (homochirality). Advances in biotechnology and chemical synthesis allow the production of the respective alternate enantiomeric form, enabling access to mirror-image versions of these natural biopolymers. Exploiting the unique properties of such mirror molecules has already led to many applications, such as biostable and nonimmunogenic therapeutics or sensors. However, a 'roadblock' for unlocking the mirror world is the lack of biological systems capable of synthesizing critical building blocks including mirror oligonucleotides and oligopeptides to reducing cost and improve purity. Here, we provide an overview of the current progress, applications, and challenges of the molecular mirror world by identifying milestones towards mirroring life.

Identifiants

DOI: 10.1016/j.tibs.2021.06.006 PMID: 34294544
pubmed: 34294544
pii: S0968-0004(21)00140-7
doi: 10.1016/j.tibs.2021.06.006
pii:
doi:

Substances chimiques

Proteins 0
RNA 63231-63-0
DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

931-943

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Fabian Rohden (F)

Alberta RNA Research and Training Institute (ARRTI), Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive, T1K 3M4, Lethbridge, Alberta, Canada.

Jörg D Hoheisel (JD)

Functional Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.

Hans-Joachim Wieden (HJ)

Alberta RNA Research and Training Institute (ARRTI), Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive, T1K 3M4, Lethbridge, Alberta, Canada; Functional Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. Electronic address: hj.wieden@uleth.ca.

Articles similaires

Exploring structural diversity across the protein universe with The Encyclopedia of Domains.

Andy M Lau, Nicola Bordin, Shaun M Kandathil et al.
1.00
Databases, Protein Protein Domains Protein Folding Proteins Deep Learning

Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottle.

Yuanyan Lou, Jianing Yan, Qingqing Liu et al.
1.00
Humans RNA, Circular Exosomes Cell Proliferation Epithelial-Mesenchymal Transition

Use of dislodgeable foliar residue studies for the evaluation of isomerization potential of active substances for non-dietary risk assessment.

Silke Wagner, Christian J Kuster
1.00
Risk Assessment Plant Leaves Isomerism Humans Stereoisomerism

iDNA-ITLM: An interpretable and transferable learning model for identifying DNA methylation.

Xia Yu, Cui Yani, Zhichao Wang et al.
1.00
DNA Methylation Humans DNA Animals Machine Learning

Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Through the looking glass: milestones on the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Through the looking glass: milestones on the...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Through the looking glass: milestones on the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Through the looking glass: milestones on the...