Pathology of autoimmune hepatitis.
autoimmune hepatitis
histology
interface hepatitis
liver biopsy
Journal
Pathologica
ISSN: 1591-951X
Titre abrégé: Pathologica
Pays: Italy
ID NLM: 0401123
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
14
12
2020
accepted:
14
12
2020
entrez:
23
7
2021
pubmed:
24
7
2021
medline:
29
10
2021
Statut:
ppublish
Résumé
Autoimmune hepatitis (AIH) is a relatively rare non-resolving chronic liver disease, which mainly affects women. It is characterized by hypergammaglobulinemia, circulating autoantibodies, interface hepatitis on liver histology and a favourable response to immunosuppression. The putative mechanism for the development of autoimmune hepatitis is thought to be the interaction between genetic predisposition, environmental triggers and failure of the native immune system. AIH still remains a major diagnostic and therapeutic challenge, mainly because it is a very heterogeneous disease. Prompt and timely diagnosis is crucial since, if left untreated, AIH has a high mortality rate. Histological demonstration of hepatitis is required for the diagnosis of AIH and, therefore, liver biopsy is mandatory in the initial diagnostic work-up, before treatment. In this review, we summarize the histological features of AIH with the main aim of highlighting the most important clinical-pathological hallmarks useful in the routine diagnostic practice.
Identifiants
pubmed: 34294936
doi: 10.32074/1591-951X-241
pmc: PMC8299324
doi:
Substances chimiques
Autoantibodies
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
185-193Informations de copyright
Copyright © 2021 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.
Références
Gut. 2011 Dec;60(12):1611-29
pubmed: 21757447
Liver Int. 2016 Sep;36(9):1362-9
pubmed: 26849025
World J Gastroenterol. 2008 Sep 21;14(35):5474-7
pubmed: 18803363
Hepatology. 2008 Sep;48(3):863-70
pubmed: 18752332
Can J Gastroenterol. 2010 Apr;24(4):225-31
pubmed: 20431809
Hepatology. 2011 Sep 2;54(3):931-9
pubmed: 21674554
Semin Liver Dis. 1996 Feb;16(1):83-95
pubmed: 8723326
J Gastroenterol. 2008;43(12):951-8
pubmed: 19107339
J Hepatol. 2009 Jun;50(6):1210-8
pubmed: 19395113
Histopathology. 2015 Feb;66(3):351-62
pubmed: 25257662
Hepat Res Treat. 2013;2013:601290
pubmed: 23555054
J Gastroenterol. 2011 Sep;46(9):1136-41
pubmed: 21597932
Aliment Pharmacol Ther. 2006 May 1;23(9):1347-53
pubmed: 16629940
J Gastroenterol. 2005 Feb;40(2):164-70
pubmed: 15770400
J Hepatol. 2011 Jul;55(1):171-82
pubmed: 21167232
Mod Pathol. 2021 Jan;34(1):233-248
pubmed: 32572157
Aliment Pharmacol Ther. 2013 Oct;38(8):887-913
pubmed: 24010812
Am J Surg Pathol. 2015 Jun;39(6):772-8
pubmed: 25634746
J Hepatol. 1995 Jun;22(6):696-9
pubmed: 7560864
Surg Pathol Clin. 2018 Jun;11(2):297-311
pubmed: 29751876
Clin Liver Dis. 2010 Nov;14(4):577-90
pubmed: 21055683
Hum Pathol. 2018 Dec;82:51-60
pubmed: 30041025
Hepatology. 2010 Jun;51(6):2193-213
pubmed: 20513004
J Hepatol. 1991 Nov;13(3):372-4
pubmed: 1808228
J Hepatol. 2008 Jan;48(1):140-7
pubmed: 18023911
J Hepatol. 2015 Oct;63(4):971-1004
pubmed: 26341719
Clin Liver Dis. 2015 Feb;19(1):57-79
pubmed: 25454297
Dig Dis Sci. 2012 Mar;57(3):610-24
pubmed: 22187100
Gastroenterology. 1995 Jun;108(6):1770-7
pubmed: 7768382
Hepatol Res. 2011 Jun;41(6):498-504
pubmed: 21595804
Hepatology. 1997 Sep;26(3):561-6
pubmed: 9303483
Dig Dis. 2015;33 Suppl 2:53-64
pubmed: 26642062
J Gastroenterol. 2011 Mar;46(3):378-90
pubmed: 20821236
Best Pract Res Clin Gastroenterol. 2011 Dec;25(6):689-700
pubmed: 22117635
Clin Rev Allergy Immunol. 2015 Jun;48(2-3):226-35
pubmed: 25051956
J Clin Pathol. 2006 Mar;59(3):246-9
pubmed: 16505273
J Viral Hepat. 2014 Feb;21(2):78-89
pubmed: 24383921
Aliment Pharmacol Ther. 2006 Oct 1;24(7):1051-7
pubmed: 16984499
Liver Int. 2018 Feb;38(2):198-209
pubmed: 28865179
Gut Liver. 2020 Jul 15;14(4):430-438
pubmed: 32301319
Hepatology. 1994 Jul;20(1 Pt 1):15-20
pubmed: 8020885
Arch Pathol Lab Med. 2000 Jan;124(1):71-81
pubmed: 10629135
Clin Rheumatol. 2008 Nov;27(11):1399-402
pubmed: 18500432
Hepatol Res. 2003 Mar;25(3):263-270
pubmed: 12697247
Hepatology. 2001 Oct;34(4 Pt 1):659-65
pubmed: 11584360
Hepatol Int. 2012 Jan;6(1):379-85
pubmed: 21557024
Anticancer Res. 2013 Feb;33(2):665-9
pubmed: 23393365
Clin Liver Dis (Hoboken). 2020 Apr 04;15(3):129-132
pubmed: 32257125
J Hepatol. 1999 Nov;31(5):929-38
pubmed: 10580593
Mod Pathol. 2017 May;30(5):773-783
pubmed: 28106105
Hepatology. 1993 Oct;18(4):998-1005
pubmed: 8406375
Hepatology. 2008 Jul;48(1):169-76
pubmed: 18537184
Hum Pathol. 2020 Feb;96:34-38
pubmed: 31666196
Dig Dis Sci. 2011 Feb;56(2):578-85
pubmed: 21046244