Vancomycin and daptomycin modulate the innate immune response in a murine model of LPS-induced sepsis.
Animals
Anti-Bacterial Agents
/ pharmacology
Cytokines
/ metabolism
Daptomycin
/ pharmacology
Dendritic Cells
/ drug effects
Immunity, Innate
/ drug effects
Leukocyte Count
Lipopolysaccharides
Macrophages, Peritoneal
/ drug effects
Male
Mice
Mice, Inbred C57BL
Peritoneal Cavity
/ cytology
Phagocytosis
/ drug effects
Sepsis
/ chemically induced
Vancomycin
/ pharmacology
antibiotics
dendritic cells
immunomodulatory properties
macrophages
neutrophils
phagocytosis
Journal
International journal of immunopathology and pharmacology
ISSN: 2058-7384
Titre abrégé: Int J Immunopathol Pharmacol
Pays: England
ID NLM: 8911335
Informations de publication
Date de publication:
Historique:
entrez:
23
7
2021
pubmed:
24
7
2021
medline:
11
1
2022
Statut:
ppublish
Résumé
Sepsis is a leading cause of death worldwide, despite the use of multimodal therapies. Common antibiotic regimens are being affected by a rising number of multidrug-resistant pathogens, and new therapeutic approaches are therefore needed. Antibiotics have immunomodulatory properties which appear to be beneficial in the treatment of sepsis. We hypothesized that the last-resort antibiotics vancomycin (VAN) and daptomycin (DMC) modulate cell migration, phagocytosis, and protein cytokine levels in a murine model of lipopolysaccharide (LPS)-induced sepsis. Ten to twelve-week-old C57BL/6 mice (
Identifiants
pubmed: 34296627
doi: 10.1177/20587384211031373
pmc: PMC8312155
doi:
Substances chimiques
Anti-Bacterial Agents
0
Cytokines
0
Lipopolysaccharides
0
Vancomycin
6Q205EH1VU
Daptomycin
NWQ5N31VKK
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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