Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development.

Endoplasmic Reticulum / metabolism Energy Metabolism GTP Phosphohydrolases / genetics Mitochondria / genetics Mitochondrial Proteins / genetics
Ca2+ ER-mitochondria tethering Mfn2 neuritic growth

Journal

EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049

Informations de publication

Date de publication:
06 09 2021
Historique:
revised: 10 06 2021
received: 22 10 2020
accepted: 23 06 2021
pubmed: 24 7 2021
medline: 25 2 2023
entrez: 23 7 2021
Statut: ppublish

Résumé

Mfn2 is a mitochondrial fusion protein with bioenergetic functions implicated in the pathophysiology of neuronal and metabolic disorders. Understanding the bioenergetic mechanism of Mfn2 may aid in designing therapeutic approaches for these disorders. Here we show using endoplasmic reticulum (ER) or mitochondria-targeted Mfn2 that Mfn2 stimulation of the mitochondrial metabolism requires its localization in the ER, which is independent of its fusion function. ER-located Mfn2 interacts with mitochondrial Mfn1/2 to tether the ER and mitochondria together, allowing Ca

Identifiants

DOI: 10.15252/embr.202051954 PMID: 34296790 PMC: PMC8419703
pubmed: 34296790
doi: 10.15252/embr.202051954
pmc: PMC8419703
doi:

Substances chimiques

Mitochondrial Proteins 0
GTP Phosphohydrolases EC 3.6.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e51954

Informations de copyright

© 2021 The Authors. Published under the terms of the CC BY NC ND 4.0 license.

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Auteurs

Sergi Casellas-Díaz (S)

Department of Cell Biology, Physiology and Immunology, Celltec-UB, University of Barcelona, Barcelona, Spain.
Institute of Neurosciences, University of Barcelona, Barcelona, Spain.

Raquel Larramona-Arcas (R)

Department of Cell Biology, Physiology and Immunology, Celltec-UB, University of Barcelona, Barcelona, Spain.
Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
ORCID: 0000-0001-8427-8007

Guillem Riqué-Pujol (G)

Department of Cell Biology, Physiology and Immunology, Celltec-UB, University of Barcelona, Barcelona, Spain.
Institute of Neurosciences, University of Barcelona, Barcelona, Spain.

Paula Tena-Morraja (P)

Department of Cell Biology, Physiology and Immunology, Celltec-UB, University of Barcelona, Barcelona, Spain.
Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
ORCID: 0000-0002-7617-3392

Claudia Müller-Sánchez (C)

Department of Cell Biology, Physiology and Immunology, Celltec-UB, University of Barcelona, Barcelona, Spain.
ORCID: 0000-0002-3654-2683

Marc Segarra-Mondejar (M)

Department of Cell Biology, Physiology and Immunology, Celltec-UB, University of Barcelona, Barcelona, Spain.
Institute of Neurosciences, University of Barcelona, Barcelona, Spain.

Aleix Gavaldà-Navarro (A)

Department of Biochemistry and Molecular Biomedicine, University of Barcelona, Barcelona, Spain.
Institute of Biomedicine, University of Barcelona, Barcelona, Spain.
CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), Madrid, Spain.

Francesc Villarroya (F)

Department of Biochemistry and Molecular Biomedicine, University of Barcelona, Barcelona, Spain.
Institute of Biomedicine, University of Barcelona, Barcelona, Spain.
CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), Madrid, Spain.
ORCID: 0000-0003-1266-9142

Manuel Reina (M)

Department of Cell Biology, Physiology and Immunology, Celltec-UB, University of Barcelona, Barcelona, Spain.

Ofelia M Martínez-Estrada (OM)

Department of Cell Biology, Physiology and Immunology, Celltec-UB, University of Barcelona, Barcelona, Spain.
Institute of Biomedicine, University of Barcelona, Barcelona, Spain.

Francesc X Soriano (FX)

Department of Cell Biology, Physiology and Immunology, Celltec-UB, University of Barcelona, Barcelona, Spain.
Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
ORCID: 0000-0003-1678-7162

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › Mfn2 localization in the ER is necessary for...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Mfn2 localization in the ER is necessary for...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Acid anhydride hydrolases › dGTPases › Mfn2 localization in the ER is necessary for...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mfn2 localization in the ER is necessary for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Mfn2 localization in the ER is necessary for...