Development of Randomized Trials in Adults with Medulloblastoma-The Example of EORTC 1634-BTG/NOA-23.
adult
cerebrospinal fluid
chemotherapy
clinical trial
magnetic resonance imaging
medulloblastoma
radiotherapy
randomized
subgrouping
targeted therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
09 Jul 2021
09 Jul 2021
Historique:
received:
16
06
2021
revised:
07
07
2021
accepted:
08
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
25
7
2021
Statut:
epublish
Résumé
Medulloblastoma is a rare brain malignancy. Patients after puberty are rare and bear an intermediate prognosis. Standard treatment consists of maximal resection plus radio-chemotherapy. Treatment toxicity is high and produces disabling long-term side effects. The sonic hedgehog (SHH) subgroup is highly overrepresented in the post-pubertal and adult population and can be targeted by smoothened (SMO) inhibitors. No practice-changing prospective randomized data have been generated in adults. The EORTC 1634-BTG/NOA-23 trial will randomize patients between standard-dose vs. reduced-dosed craniospinal radiotherapy and SHH-subgroup patients between the SMO inhibitor sonidegib (Odomzo
Identifiants
pubmed: 34298664
pii: cancers13143451
doi: 10.3390/cancers13143451
pmc: PMC8303185
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Deutsche Krebshilfe
ID : 70113453
Organisme : Cancer Australia
ID : 1165910
Organisme : CanTeen
ID : none
Organisme : KWF Kankerbestrijding
ID : 2021-1/13555
Organisme : Ministère des Affaires Sociales et de la Santé
ID : PHRC-K20-179
Organisme : Swiss Brain Tumor Foundation
ID : none
Organisme : EORTC Brain Tumor Group
ID : none
Organisme : Sun Pharmaceuticals Industries Ltd.
ID : none
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