Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease.
Alarmins
/ metabolism
Animals
Aquaporins
/ analysis
Collagen
/ analysis
Contrast Media
Cytokines
/ metabolism
Elasticity Imaging Techniques
/ methods
Endopeptidases
/ analysis
Fatty Acids
/ metabolism
Fibroblasts
/ chemistry
Fluorine Radioisotopes
Gallium Radioisotopes
Hepatic Stellate Cells
/ chemistry
Hepatocytes
/ metabolism
Humans
Liver Cirrhosis
/ diagnostic imaging
Membrane Proteins
/ analysis
Mice
Molecular Imaging
/ methods
Non-alcoholic Fatty Liver Disease
/ complications
Positron-Emission Tomography
/ methods
Radiopharmaceuticals
Rats
Receptors, CCR2
/ analysis
Triglycerides
/ metabolism
NASH
collagen
fibroblasts
fibrosis
imaging
immune cells
positron emission tomography
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Jul 2021
08 Jul 2021
Historique:
received:
25
05
2021
revised:
30
06
2021
accepted:
06
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
18
8
2021
Statut:
epublish
Résumé
Pathological fibrosis of the liver is a landmark feature in chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Diagnosis and assessment of progress or treatment efficacy today requires biopsy of the liver, which is a challenge in, e.g., longitudinal interventional studies. Molecular imaging techniques such as positron emission tomography (PET) have the potential to enable minimally invasive assessment of liver fibrosis. This review will summarize and discuss the current status of the development of innovative imaging markers for processes relevant for fibrogenesis in liver, e.g., certain immune cells, activated fibroblasts, and collagen depositions.
Identifiants
pubmed: 34298967
pii: ijms22147348
doi: 10.3390/ijms22147348
pmc: PMC8306605
pii:
doi:
Substances chimiques
Alarmins
0
Aquaporins
0
CCR2 protein, human
0
Ccr2 protein, mouse
0
Contrast Media
0
Cytokines
0
Fatty Acids
0
Fluorine Radioisotopes
0
Gallium Radioisotopes
0
Membrane Proteins
0
Radiopharmaceuticals
0
Receptors, CCR2
0
Triglycerides
0
Collagen
9007-34-5
Gallium-68
98B30EPP5S
Endopeptidases
EC 3.4.-
fibroblast activation protein alpha
EC 3.4.21.-
Fluorine-18
GZ5I74KB8G
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : EFSD/Lilly
ID : no applicable
Organisme : Magnus Bergvalls Foundation
ID : no applicable
Organisme : the Swedish Research Council
ID : no applicable
Organisme : Science for Life Laboratory
ID : no applicable
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