Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice.

Alcoholic Intoxication / etiology Animals Brain / drug effects Central Nervous System Depressants / toxicity Ethanol / toxicity Female Flavonols / blood Male Mice Mice, Inbred C57BL
GABAA receptors acute alcohol intoxication alcohol use disorder bioavailability dihydromyricetin loss of righting reflex metabolism

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
12 Jul 2021
Historique:
received: 14 06 2021
revised: 07 07 2021
accepted: 09 07 2021
entrez: 24 7 2021
pubmed: 25 7 2021
medline: 31 7 2021
Statut: epublish

Résumé

Dihydromyricetin is a natural bioactive flavonoid with unique GABA

Identifiants

DOI: 10.3390/ijms22147460 PMID: 34299083 PMC: PMC8307506
pubmed: 34299083
pii: ijms22147460
doi: 10.3390/ijms22147460
pmc: PMC8307506
pii:
doi:

Substances chimiques

Central Nervous System Depressants 0
Flavonols 0
Ethanol 3K9958V90M
dihydromyricetin KD8QND6427

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : R01AA022448
Pays : United States
Organisme : New Jersey Agricultural Experiment Station
ID : NJ06280
Organisme : New Jersey Health Foundation
ID : NJ12170

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Auteurs

Eileen Carry (E)

Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
New Use Agriculture & Natural Plant Products Program, Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
Department of Molecular Design and Synthesis, Office of Research and Economic Development, Rutgers University, Piscataway, NJ 08854, USA.
ORCID: 0000-0002-1488-3567

Dushyant Kshatriya (D)

Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.

Joshua Silva (J)

Titus Family Department of Clinical Pharmacy, School of Pharmacy, University Southern California, Los Angeles, CA 90089, USA.
ORCID: 0000-0002-2010-729X

Daryl L Davies (DL)

Titus Family Department of Clinical Pharmacy, School of Pharmacy, University Southern California, Los Angeles, CA 90089, USA.

Bo Yuan (B)

New Use Agriculture & Natural Plant Products Program, Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.

Qingli Wu (Q)

Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
New Use Agriculture & Natural Plant Products Program, Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.

Harna Patel (H)

New Use Agriculture & Natural Plant Products Program, Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.

Elizabeth R Park (ER)

Department of Molecular Design and Synthesis, Office of Research and Economic Development, Rutgers University, Piscataway, NJ 08854, USA.

John Gilleran (J)

Department of Molecular Design and Synthesis, Office of Research and Economic Development, Rutgers University, Piscataway, NJ 08854, USA.

Lihong Hao (L)

Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
ORCID: 0000-0001-7795-6981

Jacques Roberge (J)

Department of Molecular Design and Synthesis, Office of Research and Economic Development, Rutgers University, Piscataway, NJ 08854, USA.
ORCID: 0000-0002-7810-4139

Nicholas T Bello (NT)

Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
ORCID: 0000-0001-5300-5604

James E Simon (JE)

Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
New Use Agriculture & Natural Plant Products Program, Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Troubles liés à l'alcool › Intoxication alcoolique › Identification of Dihydromyricetin and...
questionsmedicales.fr › Eucaryotes › Animaux › Identification of Dihydromyricetin and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Identification of Dihydromyricetin and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Identification of Dihydromyricetin and...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Identification of Dihydromyricetin and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavonols › Identification of Dihydromyricetin and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Identification of Dihydromyricetin and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Identification of Dihydromyricetin and...