Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells.
Adolescent
Azetidines
/ pharmacology
Cells, Cultured
Child, Preschool
Enzyme Inhibitors
/ pharmacology
Farnesyltranstransferase
/ adverse effects
Female
Humans
Janus Kinase 1
/ antagonists & inhibitors
Janus Kinase Inhibitors
/ pharmacology
Male
Piperidines
/ adverse effects
Progeria
/ chemically induced
Purines
/ pharmacology
Pyrazoles
/ pharmacology
Pyridines
/ adverse effects
STAT1 Transcription Factor
/ antagonists & inhibitors
Sulfonamides
/ pharmacology
JAK-STAT
age-related disease
baricitinib
farnesyltransferase inhibitor
inflammation
lamin
progeria
progerin
replicative senescence
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Jul 2021
12 Jul 2021
Historique:
received:
02
06
2021
revised:
06
07
2021
accepted:
08
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
31
7
2021
Statut:
epublish
Résumé
Hutchinson-Gilford progeria syndrome (HGPS) is an ultra-rare multisystem premature aging disorder that leads to early death (mean age of 14.7 years) due to myocardial infarction or stroke. Most cases have a de novo point mutation at position G608G within exon 11 of the
Identifiants
pubmed: 34299092
pii: ijms22147474
doi: 10.3390/ijms22147474
pmc: PMC8307450
pii:
doi:
Substances chimiques
Azetidines
0
Enzyme Inhibitors
0
Janus Kinase Inhibitors
0
Piperidines
0
Purines
0
Pyrazoles
0
Pyridines
0
STAT1 Transcription Factor
0
STAT1 protein, human
0
Sulfonamides
0
Farnesyltranstransferase
EC 2.5.1.29
JAK1 protein, human
EC 2.7.10.2
Janus Kinase 1
EC 2.7.10.2
lonafarnib
IOW153004F
baricitinib
ISP4442I3Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 646337
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